They have succeeded in making whole mouse brains transparent and then to reconstruct parts of their neuronal networks with a computer. During their investigations at the MPI of Psychiatry they put mouse brains in an oil solution which rendered the brains completely transparent, as now published in Nature Methods. They transilluminated these transparent brains with a laser from the side layer by layer. This way, green fluorescence was induced in genetically marked nerve cells.
Using the many images from their “ultramicroscope” the scientists in the research group of the medical doctor and physicist Hans-Ulrich Dodt were able to reconstruct parts of the neuronal network in three dimensions, comparable to computer tomography but with much higher resolution.
Prof. Dodt who was appointed to the chair of Bioelectronics of the TU Vienna in January, plans to utilize this method to investigate the complex neuronal networks of the cortex. The scientists are interested to see if it is possible to visualize alterations at nerve cells after learning using this method. Ultramicroscopy will also be used to investigate the development of neuronal diseases like Alzheimer`s in mice. Besides science, the technique also has an aesthetic aspect: One can simulate a fly-through the brain using the recorded data. Therefore in the future the technique of the glass brain will be used probably for teaching students employing a “Playstation Brain”.
Werner Sommer | alfa
Gene therapy shows promise for treating Niemann-Pick disease type C1
27.10.2016 | NIH/National Human Genome Research Institute
'Neighbor maps' reveal the genome's 3-D shape
27.10.2016 | International School of Advanced Studies (SISSA)
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
27.10.2016 | Materials Sciences
27.10.2016 | Physics and Astronomy
27.10.2016 | Life Sciences