It is already widely known that the tumour suppressor p53 (a protein) plays a critical role in protecting us from cancer. Much of what we know about p53 comes from the work of Karen Vousden – she discovered the important factor that the loss of p53 played in the development of cervical carcinomas and linked this to a tumour virus that triggers this form of cancer.
Karen’s work also provided major insights into just how p53 is able to suppress tumour development; not only can it stop the proliferation of cancer cells but it can also cause them to suicide through the process of apoptosis.
The potential benefits of Karen’s work, for cancer patients, are enormous in terms of the development of molecules that might be used as drugs to stabilize and activate p53.
Dr Karen Vousden gained her PhD Genetics at University of London and went on to work with Professor Chris Marshall at the Institute of Cancer Research, London for her post-doc research. Further posts with the National Cancer Institute at Bethesda, USA and heading up the Human Papillomavirus Group at the Ludwig Institute for Cancer Research followed by senior positions at the NCI-FCRDC, culminated in her appointment as Director of the Beatson Institute in 2002.
Mark Burgess | alfa
New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg
Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News