It is already widely known that the tumour suppressor p53 (a protein) plays a critical role in protecting us from cancer. Much of what we know about p53 comes from the work of Karen Vousden – she discovered the important factor that the loss of p53 played in the development of cervical carcinomas and linked this to a tumour virus that triggers this form of cancer.
Karen’s work also provided major insights into just how p53 is able to suppress tumour development; not only can it stop the proliferation of cancer cells but it can also cause them to suicide through the process of apoptosis.
The potential benefits of Karen’s work, for cancer patients, are enormous in terms of the development of molecules that might be used as drugs to stabilize and activate p53.
Dr Karen Vousden gained her PhD Genetics at University of London and went on to work with Professor Chris Marshall at the Institute of Cancer Research, London for her post-doc research. Further posts with the National Cancer Institute at Bethesda, USA and heading up the Human Papillomavirus Group at the Ludwig Institute for Cancer Research followed by senior positions at the NCI-FCRDC, culminated in her appointment as Director of the Beatson Institute in 2002.
Mark Burgess | alfa
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy