There are two major strains of malaria effecting humans, P. vivax and P. falciparum. Although attention focuses on the more virulent P. falciparum, vivax malaria causes a huge amount of illness in the tropical countries of our region and puts many Australian travelers at risk of disease. Vivax malaria is becoming increasingly resistant to standard treatments, but few studies have determined the best way of treating it.
In collaboration with partners at the Indonesian Ministry of Health, the MSHR team conducted a study in Papua, where they compared, head to head, two new treatments for malaria. Both contained a combination of drug based on a Chinese herbal extract (artemisinin) with a longer acting antimalarial drug.
The researchers found that both treatments provided initial cure from disease. However those receiving a treatment which stayed in the blood stream for longer were three times less likely to have another episode of malaria within 42 days and were less likely to be anaemic.
MSHR scientist, Dr Ric Price, said that the findings have important implications for the treatment of malaria in our region and relevance to areas of Africa where the risk of malaria is greatest.
"Scientists and doctors wage a constant battle to develop and implement effective treatments for malaria. This study is one of the first to highlight the best treatment of drug resistant strains of vivax malaria found in the Asia pacific region." said Dr Price.
"It also provides evidence that longer acting drugs can prevent patients, who remain at risk of further infections, from getting sick again within 6 weeks. This "post treatment prophylaxis" is similar to the approach of giving travelers regular medication to protect them from infection, but can be applied opportunistically to people at high risk of infection in poor tropical communities." he added.
A concern with such a policy is that the resistance will emerge quickly to the long acting drug. However the team believes that by combining the two drugs will help to prevent this from happening.
Julie Carmichael | EurekAlert!
Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg
Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy