Shulamit Michaeli and colleagues describe a pathway in T. brucei parasites that they named SLS (SL-RNA silencing). Triggering this pathway shuts down the synthesis of a crucial RNA molecule, which halts the production of messenger RNAs and leads to the parasite’s death.
Inducing SLS could therefore be a novel way to eradicate parasites and prevent sleeping sickness - trypanosomiasis. The researchers also believe this could have implications for related parasites and diseases, such as Leishmania and leishmaniasis and Trypanosoma cruzi and Chagas disease.
Sleeping sickness affects humans and livestock, and is endemic in sub-Saharan Africa where it is estimated to affect as many as 70,000 people. Leishmaniasis is estimated to affect millions of individuals throughout the world, and can lead to skin lesions, tissue damage, fever, blindness and death.
Chagas disease affects 16-18 million people across the Americas, and can cause intestinal complications, neurological disorders, heart damage and death. Although drugs are available to treat these diseases, their use is hampered by toxicity and undesirable side effects, difficulties in administering treatment, an increase in drug resistance, and high costs.
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences