Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Super-fermenting fungus genome sequenced

06.03.2007
To be harnessed for improved biofuels production

On the road to making biofuels more economically competitive with fossil fuels, there are significant potholes to negotiate. For cellulosic ethanol production, one major detour has being addressed with the characterization of the genetic blueprint of the fungus Pichia stipitis, by the U.S. Department of Energy Joint Genome Institute (DOE JGI) and collaborators at the U.S. Forest Service, Forest Products Laboratory (FPL). The research, entailing the identification of numerous genes in P. stipitis responsible for its fermenting and cellulose-bioconverting prowess, and an analysis of these metabolic pathways, is featured in the March 4 advanced online publication of Nature Biotechnology.

P. stipitis is the most proficient microbial fermenter in nature of the five-carbon “wood sugar” xylose—abundant in hardwoods and agricultural leftovers, which represent a motherlode of bioenergy fodder.

“Increasing the capacity of P. stipitis to ferment xylose and using this knowledge for improving xylose metabolism in other microbes, such as Saccharomyces cerevisiae, brewer’s yeast, offers a strategy for improved production of cellulosic ethanol,” said Eddy Rubin, DOE JGI Director. “In addition, this strategy could enhance the productivity and sustainability of agriculture and forestry by providing new outlets for agricultural and wood harvest residues.”

... more about:
»DOE »Genome »JGI »Pichia »fungus »stipitis »xylose

Ligonocellulosic biomass, a complex of cellulose, hemicellulose, and lignin, is derived from such plant-based “feedstocks” as agricultural waste, paper and pulp, wood chips, grasses, or trees such as poplar, recently sequenced by DOE JGI. Under current strategies for generating lignocellulosic ethanol, these forms of biomass require expensive and energy-intensive pretreatment with chemicals and/or heat to loosen up this complex. Enzymes are then employed to break down complex carbohydrate into sugars, such as glucose and xylose, which can then be fermented to produce ethanol. Additional energy is required for the distillation process to achieve a fuel-grade product. Now, the power of genomics is being directed to optimize this age-old process.

“The information embedded in the genome sequence of Pichia has helped us identify several gene targets to improve xylose metabolism,” said Pichia paper lead author Thomas W. Jeffries of the Forest Products Laboratory in Madison, Wisconsin. “We are now engineering these genes to increase ethanol production.” Jeffries said that yeast strains like Pichia have evolved to cope with the oxygen-limited environment rich in partially digested wood that is encountered in the gut of insects, from where the sequenced strain was originally isolated.

FPL has a Cooperative Research and Development Agreement (CRADA) in place with a New York City-based bioenergy company, Xethanol Corporation, which plans to integrate Dr. Jeffries’ findings into its large-scale biofuels production processes.

Pichia joins white rot fungus in the growing portfolio of bioenergy-relevant fungus genomes sequenced by DOE JGI through its user programs and contributed freely to the worldwide scientific community.

David Gilbert | EurekAlert!
Further information:
http://www.llnl.gov

Further reports about: DOE Genome JGI Pichia fungus stipitis xylose

More articles from Life Sciences:

nachricht Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie

nachricht Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>