Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Comparison of immune response to 1918 and H5N1 influeza viruses shows similarities

01.03.2007
A comparison of the 1918 Spanish influenza and the H5N1 avian influenza viruses suggests that while the two viruses appear to trigger a similar abnormal immune response in animal models, there are distinct differences. Researchers from the University of Washington School of Medicine in Seattle report their findings today at the ASM Biodefense and Emerging Disease Research Meeting.

"The influenza pandemic of 1918-19 was responsible for at least 40 million deaths worldwide. Recent experiments in mouse and nonhuman primates have suggested a central role of the host immune response in 1918 and H5N1 disease severity," says John Kash, a lead researcher on the study.

Kash and his colleagues have previously published research on how the immune system responds to infection with the 1918 virus in mouse and nonhuman primate lungs, using bioinformatic tools to see what genes within the immune system are expressed in response to infection. They discovered that the virus caused an almost immediate and overwhelming immune system response that basically turned the immune systems of its victims against them.

In the current study, Kash and colleagues examined the gene expression in response to H5N1 avain influenza virus in mouse lungs and compared the immune response to the previously collected data on the 1918 influenza virus.

... more about:
»H5N1 »Kash »immune system

"It looks like both these viruses elicit some sort of overblown inflammatory response. While at a fundamental level they look very similar to each other, there are subtle distinctions," says Kash.

In studying these commonalities and differences, Kash hopes to better understand how the viruses cause disease and hopefully develop new treatments. Eventually scientists may be able to develop drugs that could turn down or even switch off the unwanted activity while still allowing the immune system to combat the infection.

"What we are trying to do is understand the similarities and differences and what they mean. If we can understand those common mechanisms, we can better develop new treatments for the disease," says Kash.

Jim Sliwa | EurekAlert!
Further information:
http://www.asmusa.org

Further reports about: H5N1 Kash immune system

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>