Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study of atomic movement may influence design of pharmaceuticals

28.02.2007
Chemists at the University of Liverpool have designed a unique structure to capture the movement of atoms which may impact on future designs of pharmaceuticals

The research, funded by the Engineering and Physical Sciences Research Council (EPSRC), will further understanding of how to control chemical reactions and will influence improvements in a range of important processes from the design of biopharmaceuticals to the engineering of new catalysts, enabling scientists, for example, to develop products in more environmentally friendly ways.

The Liverpool team created a porous crystal which has 'walls' of atoms and cavities which act as containers for molecules. They used this crystal to accommodate a set of molecules as they took part in a chemical reaction similar to reactions by enzymes and proteins to regulate and keep alive living systems.

The crystal was put into a powerful X-ray diffraction machine at Daresbury laboratory, Warrington. This allowed scientists to pinpoint precisely the positions of individual atoms, providing snapshots of their movement. Because the reaction was carried out within the cavities of the crystal, the team was able to locate the positions of the atoms both before and after the reaction. This is the first time that the positions of atoms both at the beginning and the end of a chemical process have been seen.

Professor Matthew Rosseinsky explains: "To design more efficient processes which run with less waste and less energy input, scientists need a better understanding of the way in which atoms move during chemical reactions. We designed a robust structure that remained stable when a chemical reaction occurred inside its walls – a structure with an opening the same size as a single molecule of aspirin. The X-ray experiment then allowed us to see how the entire structure changed during the chemical process.

"Chemical reactions are essential in key manufacturing methods and in maintaining life in living systems and so this new research could influence the understanding of a wide range of important processes. This includes the chemical reactions involved in the production of anti-cancer drugs as well as reactions which allow biological molecules in plants and animals to convert food into energy."

Samantha Martin | EurekAlert!
Further information:
http://www.liv.ac.uk

Further reports about: Design Influence chemical reaction structure

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>