Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery of chemical profiles for infectious diarrhea

28.02.2007
Academics have found, for the first time, smells from healthy faeces and people with infectious diarrhoea differ significantly in their chemical composition and could be used to diagnose quickly diseases such as Clostridium difficile (C. Diff.).

It is hoped the discovery of these chemical profiles will lead to the development of a device capable of rapid diagnosis at the bedside, saving both time and money.

The study, published online in The FASEB Journal, is the result of a joint collaboration between Dr Chris Probert, Consultant and Reader in Gastroenterology at Bristol University and Professor Norman Ratcliffe at the University of the West of England.

For a long time it has been known that stools have distinctive and different odours if there is an infection. What the researchers have done is to take this 'knowledge' a step further by analysing the odour of healthy donors and patients with gastrointestional disease to see if precise chemical profiles can be established.

The researchers compared faeces of healthy donors together with patients with ulcerative colitis, Campylobacter jejuni and Clostridium difficile (C. Diff.) and found their chemical composition were each significantly different.

The next stage of the academics research is to develop a prototype rapid diagnosis device able to be operated by healthcare staff at all levels.

Dr Chris Probert said: "The discovery of chemical profiles is a major step forward in the diagnosis and treatment of people with gastrointestinal disease. Early treatment of Clostridium difficile means patients have a much better chance of survival and fewer complications. However, at present the average length of time taken to diagnose the condition is eight days. "

Two of the most common types of infectious diarrhoea are Campylobacter jejuni and Clostridium difficile (C. Diff.). Although less well known than the MRSA superbug, C. Diff. is just as serious, and affects more than 50,000 people each year in England and Wales at a cost to the NHS of around £60 million.

Dr Chris Probert added: "There is a huge potential for a rapid diagnosis device in the UK, 30,000 samples are tested in Bristol alone each year. However, the device could be adapted for use in developing countries where 7,000 children die as a result of diarrhoea every day. Our next aim is to produce a prototype device capable of diagnosing at any healthcare setting."

Professor Norman Ratcliffe, from the University of the West of England, added: "There are numerous different kinds of infection that cause diarrhoea and a speedy diagnosis would lead to more appropriate use of antibiotics. A rapid diagnosis device has the potential to save lives and reduce the cost burden to the NHS. Early isolation of infectious patients would reduce hospital outbreaks leading to fewer ward/hospital closures. "

"Rapid diagnosis of intestinal illnesses is as useful a contribution to public health as one could imagine," said Gerald Weissman, M.D., editor-in-chief of the FASEB Journal. "The method developed by Garner et al is not only useful, but also imaginative."

Joanne Fryer | EurekAlert!
Further information:
http://www.bristol.ac.uk

Further reports about: Clostridium Infectious Rapid diagnosis diarrhoea difficile

More articles from Life Sciences:

nachricht The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences

nachricht Transforming plant cells from generalists to specialists
07.12.2016 | Duke University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>