Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

'Caged DNA' can be freed for gen therapy

27.02.2007
By combining DNA macromolecules with polymers containing iron, molecular ‘cages’ can be made: porous structures capable of carrying and delivering drugs or DNA-fragments.

By using small molecules as keys, the cage can be opened or part of the DNA can be freed. Scientists of the MESA+ Institute for Nanotechnology of the University of Twente in The Netherlands report about this in Angewandte Chemie International Edition, in their cover article on February 26, 2007.

DNA, being the carrier of genetic information in living creatures, can also be used in man-made technology, for instance in bioinformatics and DNA-computing. Scientists Yujie Ma and Mark Hempenius of the University of Twente managed to combine DNA macromolecules with synthetic polymers containing iron. The result is a novel way of creating porous structures, spherical ‘cages’ for example.

The walls of these cages are built step by step. The scientist therefore ingeniously use the different properties the two types of molecules have. DNA has a negative electrical charge while the polymer containing iron is positively charged. Another essential features of DNA is that the molecule is much more rigid than the polymer. The polymer wraps around the DNA and forms a very stable couple with it. What binds them together are electrostatic forces.

... more about:
»DNA »Gen »Iron »Polymer

‘Key molecules’

The spherical cage can transport medicine and deliver it locally. The cage can be opened by letting small molecules function as ‘keys’: they oxidize the iron and break the bond between the DNA and the polymer locally. In the same way, it is possible to free DNA-fragments from the cage, and apply them in gen therapy. Genes are then inserted into cells and tissue to treat inherited disease.

Macroporous materials like the new cages, with pore sizes larger than 50 nanometers, have a wide range of possible applications, but they are not easily fabricated until now. The DNA-polymer combination is an example of ‘self-assembly’ in which molecules organize themselves. It is a powerful new method to create the materials and an important step towards innovative applications.

The research, led by prof. Julius Vancso of the MESA+ Institute for Nanotechnology of the University of Twente and prof. Helmuth Möhwald of the Max-Planck-Institut für Kolloid- und Grenzflächenforschung in Golm, Germany, is published in the February 26 issue of Angewandte Chemie International.

Wiebe van der Veen | alfa
Further information:
http://www.utwente.nl
http://www3.interscience.wiley.com/cgi-bin/fulltext/114095845/HTMLSTART

Further reports about: DNA Gen Iron Polymer

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>