Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

2,000 influenza virus genomes now completed and publicly accessible

22.02.2007
Information critical to developing treatments and vaccines

The Influenza Genome Sequencing Project, funded by the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), announced today that it has achieved a major milestone. The entire genetic blueprints of more than 2,000 human and avian influenza viruses taken from samples around the world have been completed and the sequence data made available in a public database.

"This information will help scientists understand how influenza viruses evolve and spread," says NIH Director Elias A. Zerhouni, M.D., "and it will aid in the development of new flu vaccines, therapies and diagnostics."

"Scientists around the world can use the sequence data to compare different strains of the virus, identify the genetic factors that determine their virulence, and look for new therapeutic, vaccine and diagnostic targets," says NIAID Director Anthony S. Fauci, M.D.

... more about:
»Genom »Influenza »Virus »flu

The Influenza Genome Sequencing Project, initiated in 2004, has been carried out at the NIAID-funded Microbial Sequencing Center managed by The Institute for Genomic Research (TIGR) of Rockville, Maryland. The project is currently directed by David Spiro, Ph.D., and Claire Fraser, Ph.D., at TIGR and Elodie Ghedin, Ph.D., at the University of Pittsburgh School of Medicine. Recently, growing sequencing capacity has enabled the production rate to increase to more than 200 viral genomes per month. Eclipsing today’s milestone of 2,000 genomes, the microbial sequencing center will continue to rapidly sequence more influenza strains and isolates and will make all the sequence data freely available to the scientific community and the public through GenBank, an Internet-accessible database of genetic sequences maintained by the National Center for Biotechnology Information (NCBI) at NIH’s National Library of Medicine, another major contributor to the project.

Seasonal influenza is a major public health concern in the United States, accounting for approximately 36,000 deaths and 200,000 hospitalizations each year. Globally, influenza results in an estimated 250,000 to half a million deaths annually. Seasonal flu shots are updated every year to target the latest strains in circulation. Developing such vaccines is challenging, however, because the influenza virus is prone to high mutation rates when it replicates, and these mutations can alter the virus enough that vaccines against one strain may not protect against another strain.

An even greater concern is the potential for an influenza pandemic caused by the emergence of a new, highly lethal virus strain that is easily transmitted from person to person. Influenza pandemics have occurred three times in the last century, the most lethal of which was the pandemic of 1918, which caused an estimated 40 to 50 million deaths worldwide.

"A few years ago, only limited genetic information on influenza viruses existed in the public domain, and much of the sequence data was incomplete," says Maria Y. Giovanni, Ph.D., who oversees the NIAID Microbial Sequencing Centers. "The Influenza Genome Sequencing Project has filled that gap by vastly increasing the amount of influenza sequence data and rapidly making it available to the entire scientific community. Subsequently, there has been a marked increase in the number of scientists worldwide depositing influenza genome sequence data into the public domain including scientists at St. Jude Children’s Research Hospital and the Centers for Disease Control and Prevention."

Jason Socrates Bardi | EurekAlert!
Further information:
http://www.niaid.nih.gov

Further reports about: Genom Influenza Virus flu

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>