Work in his laboratory shows that TCTP plays a role in regulating Rheb (Ras homologue enriched in brain), a protein controlling growth and differentiation, and may give clues to treatment of a particular benign disease called tuberous sclerosis that is associated with the control exerted through the same pathway, said Dr. Kwang-Wook Choi, associate professor of molecular and cellular biology at BCM and his colleagues.
When flies completely lack the protein, they do not live very long. However, when flies have only a little TCTP in their cells, they are very small, said Choi. Graduate student Ya-Chieh Hsu, through a series of studies that concentrated on the effect of the protein on the eyes and wings, elucidated the role of TCTP in the cell.
"She was able to show genetically and biochemically that TCTP is directly involved in regulating Rheb function so that it regulates cell size as well as cell numbers. We found that in the case of dysfunction, the eyes and wings get smaller," said Choi. "If you completely knock out this function in the eye, they have no eyes."
TCTP was of interest because it is over-expressed or overabundant in cancer cells.
"If you reduce the levels of TCTP, tumor cells revert to normal in the laboratory," said Choi. However, in their studies of fruit flies, Choi and his colleagues found when the protein is lacking, it has a profound effect on flies. However, too much does not cause tumor growth. Choi is also a faculty member of the BCM Graduate School of Biomedical Sciences.
Laura Madden-Fuentes | EurekAlert!
Fungi that evolved to eat wood offer new biomass conversion tool
25.07.2017 | University of Massachusetts at Amherst
New map may lead to drug development for complex brain disorders, USC researcher says
25.07.2017 | University of Southern California
Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers
Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...
Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.
At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...
3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects
A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
21.07.2017 | Event News
19.07.2017 | Event News
12.07.2017 | Event News
25.07.2017 | Earth Sciences
25.07.2017 | Life Sciences
25.07.2017 | Life Sciences