This genetic study, published today in the journal Nature, was led by MUHC endocrinologist Dr. Rob Sladek at the McGill University and Genome Quebec Innovation Centre together with Dr. Constantin Polychronakos at the MUHC and Dr. Philippe Froguel at the Pasteur Institute (Lille, France). The study also involved scientists at the University of Montreal, Imperial College (London, UK) and the Montreal Diabetes Research Centre.
Sladek and his colleagues systematically searched the entire human genome to identify genes that predispose individuals to developing diabetes. By comparing hundreds of thousands of DNA fragments from patients with diabetes to those from non-diabetic individuals, they discovered that patients who developed diabetes shared common gene variants on chromosomes 8, 10 and 11.
“Of the four genes we have identified, two are involved in the development or function of insulin-secreting cells and one plays a role in the transport of zinc, an important mineral required for the production of insulin,” says Sladek.
“We used a totally new concept and technology to look for the genes,” says Polychronakos. “It worked very successfully and our findings are proof of principle that these approaches can be used to dissect the genetic component of other complex diseases and, eventually, other complex human traits.”
Type 2 diabetes is the most common form of diabetes in adults and is becoming increasingly common in children. It is caused by the decreased production or effect of insulin, a hormone that is secreted by the pancreas and which regulates the amount of glucose in the blood. It has been known for some time that for Type 2 diabetes is caused by a combination of genetic and lifestyle factors. The group’s new finding helps identify the population at the highest risk of developing this disease.
The research was funded by a grant from Genome Canada and Genome Quebec headed by Dr. Barry I. Posner, professor of Medicine at McGill University and the MUHC; and by a grant from the Canadian Foundation for Innovation to the Montreal Diabetes Research Centre, headed by Dr. Marc Prentki, professor of Medicine at the University of Montreal.
"In the last few years, advances in technology pioneered in Quebec, have made complex genetic analyses, such as those used in this study, possible," stated Genome Quebec President Paul L’Archevêque. "Without these advances an the collaboration between institutes, this research would not have been possible. The experimental approach used in this study, may help lead to the unraveling of other complex genetic diseases."
The Research Institute of the McGill University Health Centre (RI MUHC) is a world-renowned biomedical and health-care hospital research centre. Located in Montreal, Quebec, the institute is the research arm of the MUHC, a university health center affiliated with the Faculty of Medicine at McGill University. The institute supports over 500 researchers, nearly 1000 graduate and post-doctoral students and operates more than 300 laboratories devoted to a broad spectrum of fundamental and clinical research. The Research Institute operates at the forefront of knowledge, innovation and technology and is inextricably linked to the clinical programs of the MUHC, ensuring that patients benefit directly from the latest research-based knowledge. For further details visit: www.muhc.ca/research.
The McGill University Health Centre (MUHC) is a comprehensive academic health institution with an international reputation for excellence in clinical programs, research and teaching. The MUHC is a merger of five teaching hospitals affiliated with the Faculty of Medicine at McGill University––the Montreal Children’s, Montreal General, Royal Victoria, and Montreal Neurological Institute and Hospital, as well as the Montreal Chest Institute. Building on the tradition of medical leadership of the founding hospitals, the goal of the MUHC is to provide patient care based on the most advanced knowledge in the health care field, and to contribute to the development of new knowledge. www.muhc.ca
Génome Québec has the mission to mobilize academic and industrial sectors with regard to genomics and proteomics research. This private non-profit organization invests and manages funds totalling over $380 million from both the private and public sectors. Génome Québec presently manages projects in six major sectors, that of human health, bioinformatics, ethics, the environment, forestry and agricultural sciences. For more details on Génome Québec and genomics, visit out web site at: www.genomequebec.com.
Genome Canada is a private, non-profit corporation, and the primary funding and information source relating to genomics and proteomics in Canada. Its principal goal is to enable Canada to become a world leader in genomics and proteomics research. Its mandate is to develop and implement a national strategy in genomics and proteomics research for the benefit of all Canadians. For this purpose, it has received $600 million in funding from the Canadian government and co-funding from other partners, allowing it to invest a total of $1.4 billion in 115 innovative research projects and technology platforms. To learn more about Genome Canada, please visit our Web site at www.genomecanada.ca.
Christine Zeindler | EurekAlert!
Transport of molecular motors into cilia
28.03.2017 | Aarhus University
Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Life Sciences
28.03.2017 | Information Technology
28.03.2017 | Physics and Astronomy