Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New protein super-family discovered with critical functions for animal life

14.02.2007
The following press release refers to an upcoming article in PLoS ONE. The release has been provided by the article authors and/or their institutions. Any opinions expressed in this are the personal views of the contributors, and do not necessarily represent the views or policies of PLoS. PLoS expressly disclaims any and all warranties and liability in connection with the information found in the release and article and your use of such information.

Biologists have discovered a new super-family of developmental proteins that are critical for cell growth and differentiation and whose further study is expected to benefit research on cancer and the nerve-cell repair.

The protein super-family, which existed before the emergence of animals about 850 million years ago, is of major importance for understanding how life evolved in primordial times. The discovery will be described in the 14 February 2007 issue of the journal PLoS ONE.

"This super-family is highly divergent, even in animals with an ancient lineage such as the sea anemone. This super-family also evolves rapidly, so its proteins may provide a model system for investigating how rapidly mutating genes contribute to, and are likely necessary for, the diversity and adaptability of animal life," explains Penn State Assistant Professor Randen Patterson, the senior author of the study. The new protein superfamily is named "DANGER," an acronym for "Differentiation and Neuronal Growth Evolve Rapidly."

... more about:
»DANGER »Genome »PLoS »Patterson »super-family

The discovery was led by Patterson and Damian van Rossum, a postdoctoral scholar at Penn State in University Park, Pennsylvania, and collaborators at Johns Hopkins University in Baltimore, Maryland. "Most DANGER proteins have not been researched, but from what little we do know these proteins, they are critical for cell growth and differentiation," van Rossum says.

Because so many genomes for diverse organisms have been sequenced and annotated, the discovery of a new and deeply rooted protein family is quite rare. The relationship of the six family members comprising the DANGER super-family escaped detection due to the high rates of mutations between family members, although a few family members had been detected previously and had been shown to control the differentiation of cells into organs in worms, fish, and mice. Deletion of these their DANGER genes led to gross structural changes and prenatal death.

These findings also have clinical relevance, according to the researchers. "Many DANGER proteins are surrounded by transposable elements, which are pieces of DNA around genes that help the genes migrate back and forth throughout the genome," Patterson says. Because of this feature, DANGER genes can move throughout the genome, which could have positive or negative health consequences. "One member of the gene family resides in the genome at an area responsible for a human disease, the Smith-Magenis syndrome, which results in severe physical and mental retardation," Patterson explains. "DANGER genes also contain transposable elements that may participate in the genetic disturbances associated with chronic myeleoid leukemia."

One member of the super-family has been identified as playing a role in the development of the nervous system. "In cell culture and spinal cord neurons, the protein coded for by this gene stimulates lengthening and branching of neurons," Patterson says. Because many other DANGER proteins also are expressed in neurons, discovering their functions may be a key to deciphering the complexity of neuronal growth and development.

In addition to Patterson and van Rossum, investigators in this study include N. Nikolaidis and D. Chalkia at Penn State and D. N. Watkins, R. K. Barrow, and S. H. Snyder at Johns Hopkins. The research was supported by grants from the National Institutes of Health and the Searle Foundation.

Andrew Hyde | alfa
Further information:
http://dx.doi.org/10.1371/journal.pone.0000204
http://www.plosone.org

Further reports about: DANGER Genome PLoS Patterson super-family

More articles from Life Sciences:

nachricht Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society

nachricht 127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>