It should be noted that acute lymphoblastic leucemia is the most common oncological disease amongst children. This is why the application of this discovery could be highly beneficial for a special group of patients with this disorder – those who show the cellular control pathway known as WNT as altered, - and whose prognosis of this tumour disease is serious.
The WNT pathway is the device that a normal cell needs to activate in order to initiate a process of cell growth and which, once realised, should deactivate itself. However, it has been shown that, in those groups of acute lymphoblastic leucemia patients with the worst prognoses, this cell control pathway appears to be constantly activated. This phenomenon occurs because the mechanisms controlling this pathway have been silenced due to a process which affects gene transcription and known as metilation. The WNT pathway activated in an ongoing manner gives rise to the expression of specific genes whose function is to activate the growth of tumour cells.
Administration of new medicinal drugs
The study has shown, with in vitro trials, that administering a type of medication which impedes this process of metilation or which inactivates the WNT pathway, results in the normalisation of this cell control pathway and, so, impedes the development of tumour cells, inducing the death of the leucemia cells. In this way, this group of medicines will help to enhance chemotherapy results and raise the rates of survival amongst these patients.
The discovery provides a rational basis for being able to use a series of drugs for this disease - such as quercetine (which produces a programmed death of acute lymphoblastic leucemia cells) or Decitabine, medication, already used with other kinds of pathologies.
The next stage in the research will involve the application of trials, based on these studies, in rats, in order to determine which of these drugs are, in fact, efficacious. Once this has been determined, clinical trials with patients will be proposed.
If the results of the application of this research prove to be a success, one consequence may be that the classification of patients with acute lymphoblastic leucemia can be carried out on the basis of the state of activation of the WNT pathway, as this is considered to be a risk factor in the worsening of the disease and in its possible cure.
Irati Kortabitarte | alfa
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences