Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New player in commitment to life as a fat cell

08.02.2007
Researchers have discovered a pivotal new player in early events that commit fat cell precursors to becoming full-blown fat, according to a report in the February issue of the journal Cell Metabolism, published by Cell Press.

Drugs that block some activities of the enzyme, known as xanthine oxidoreductase (XOR), might therefore offer a novel antiobesity therapy designed to fight fat before it even forms, the researchers said.

Known for its role in producing the metabolic byproduct uric acid, XOR had earlier been implicated in gout, said Jeffrey Friedman of The Rockefeller University, senior author of the study. Gout is a painful type of arthritis that results when uric acid crystals build up in the joints.

"These findings are novel in many aspects," said Iphigenia Tzameli of Harvard Medical School, one of the study's first authors. "This enzyme was originally known in association with the catabolism of purines into uric acid, the production of reactive oxygen species, and its involvement in gout. It has never been looked at in the context of fat development before."

... more about:
»Cell »HDL-cholesterol »Precursor »XOR »uric »uric acid

The findings further suggest that adipose-tissue XOR may be a contributing factor to other symptoms commonly seen in obese individuals, including high blood levels of uric acid (hyperuricemia), the presence of plaque-forming lipids, and oxidative stress, the researchers added.

The research team, which also included Kevin Cheung of The Rockefeller University, screened fat precursor cells for genes that switch on early in the path to fat formation. Using a novel method to rank genes, they found that XOR was at the top of the list of genes that fit the profile of a fat generator.

Indeed, they found evidence that XOR controls PPAR-gamma a transcription factor considered to be the master regulator of fat production since it is both necessary and sufficient for adipose differentiation both in vitro and in vivo, the researchers said.

Treatments that inhibited XOR activity in cells blocked fat formation and PPAR-gamma activity, the researchers reported. Likewise, increased XOR levels hiked activity of the PPAR-gamma receptor in both fat cells and fat cell precursors. Mice lacking XOR showed a 50% reduction in fat tissue mass compared to their normal littermates. Genetically obese mice exhibited increased XOR activity and urate in the adipose tissue. Urate is a salt derived from uric acid.

"Our results identify XOR as a potential therapeutic target for metabolic abnormalities beyond hyperuricemia," the researchers said.

"To our knowledge, there have not been studies designed to explore the effects of XOR inhibitors on body weight, and in light of our findings, such studies may be warranted," they added.

Erin Doonan | EurekAlert!
Further information:
http://www.cell.com

Further reports about: Cell HDL-cholesterol Precursor XOR uric uric acid

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>