Once a patient undergoes surgery for the removal of their bladder and lymph nodes -- the standard treatment for muscle-invasive bladder cancer -- researchers say a routine tissue analysis could easily test for the presence of mutated proteins, or biomarkers, that they found to help ascertain the chances that the cancer will return.
The findings, which researchers say could one day alter the postoperative treatment offered to patients who test positive for the mutated biomarkers, are available online and in an upcoming issue of The Lancet Oncology.
"Our goal is to identify patients who have a higher chance of cancer recurrence," said Dr. Jose Karam, the study's lead author and a medical resident at UT Southwestern. "If we can identify key biomarker alterations in these patients, we might be able to predict who will benefit from treatments such as chemotherapy."
In the study, UT Southwestern scientists investigated the association of the proteins Bcl-2, caspase-3, P53 and survivin with the recurrence of cancer after surgery. The proteins are known to regulate apoptosis, or programmed cell death.
Apoptosis is a way for the body to safely dispose of dead cells, and it plays a role in preventing cancer. If cells don't die when they are supposed to, they can continue dividing and change into a tumor.
"We are trying to identify tumors that are more aggressive and more likely to spread," said Dr. Yair Lotan, assistant professor of urology at UT Southwestern and an author of the study. "Even after we've removed a diseased bladder and lymph nodes from a patient, more than 20 percent of patients have disease elsewhere in their body."
Researchers collected archival tissue from 226 patients who underwent surgery for bladder cancer -- the fourth most common cancer in men and the ninth most common cancer in women -- between January 1987 and December 2002. They tested the tissue for the protein biomarkers and found that patients who showed mutations in all four biomarkers had a significantly increased rate of mortality from cancer after surgery. Patients who showed no mutations in the four biomarkers had a 90 percent chance of survival at five years compared to less than 20 percent if they had four mutated markers.
Dr. Shahrokh Shariat, the study's senior author and a urology resident at UT Southwestern, said the findings suggest that mutations in the biomarkers indicate a malfunction in programmed cell death, leading to increased chances of cancer recurrence and mortality.
Dr. Karam noted that while the findings are still preliminary and need to be scientifically validated before being applied in the clinic, the results could change the treatment patients receive.
"Patients who have alterations on all four biomarkers might benefit from adjuvant chemotherapy even if the cancer appears to be confined to their bladder.
Otherwise, their chances for survival are likely to be poor," said Dr. Karam. "Likewise, those who show none of the biomarkers might not need unnecessary chemotherapy."
Connie Piloto | EurekAlert!
Researchers identify how bacterium survives in oxygen-poor environments
22.11.2017 | Columbia University
Researchers discover specific tumor environment that triggers cells to metastasize
22.11.2017 | University of California - San Diego
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
22.11.2017 | Life Sciences
22.11.2017 | Life Sciences
22.11.2017 | Materials Sciences