Recent studies have shown that this natural compound also displays anti-tumor and antiviral activities against several types of viruses, including human immunodeficiency virus (HIV). It is easily prepared and purified and has been intensively investigated by a broad spectrum of researchers over the past decade.
HA can photosensitize membrane proteins and lipids, damaging the membranes of tumor cells, which might cause them to die. In order to reveal the detailed photosensitive damage mechanism of HA at molecular level, researchers used a model protein with known structure, lysozyme. According to Jiahong Zhou, writing in the current issue of Spectroscopy: An International Journal, this mechanism has not been previously investigated.
Raman spectroscopy can probe the structure of biomolecules and can identify structural changes in proteins. The authors conclude that the active oxygen species released by HA induce dramatic changes in the structure of the lysozyme molecule. With more study of this mechanism, perhaps HA can serve as a therapeutic agent for a number of diseases.
The article is “Raman spectroscopic study of photosensitive damage to lysozyme structure sensitized by hypocrellin A” by J.H. Zhou, X.H. Wu, S.H. Wei, X.T. Gu, Y.Y. Feng, X.S. Wang and B.W. Zhang. The authors are from the Analysis & Testing Center, Nanjing Normal University, 210097 Nanjing, P.R. China, and the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 10010, P.R. China. It appears in Spectroscopy: An International Journal, Volume 20, Issue 5/6 (2007), published by IOS Press.
Astrid Engelen | alfa
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research