In addition, the bone marrow-derived stem cells, which could be differentiated into neurons and other cells making up the central nervous system, spread far and wide and behaved like neural stem cells when transplanted into the brain tissue of chicken embryos.
Results of the experiments, described in the February 2007 of the Journal of Neuroscience Research, support the concept of using bone marrow-derived stem cells to create therapies to treat brain tumors, strokes and neurodegenerative diseases. A similar study using bone marrow-derived stem cells of rats appeared as the cover article of the December 2002 issue of Experimental Neurology.
"These findings reinforce the data that came from our study of rat bone marrow-derived stem cells," said John S. Yu, M.D., neurosurgeon, co-director of the Comprehensive Brain Tumor Program, and senior author of both articles. "Using two methods, we show evidence for the bone marrow-derived stem cells being neural cells, and we demonstrate that it is feasible to grow the cells in large numbers. We also document that these cells function electrophysiologically as neurons, using similar voltage-regulating mechanisms."
Progressing from the rat study to experiments with human cells and transplantation into mammal brain tissue, the research team continues to build a foundation for translating laboratory research into human clinical trials.
"Based on our studies to date, a patient's own bone marrow appears to offer a viable and renewable source of neural stem cells, allowing us to avoid many of the issues related to other types of stem cells," said Keith L. Black, M.D., director of the Maxine Dunitz Neurosurgical Institute and chairman of Cedars-Sinai's Department of Neurosurgery.
The replacement of damaged brain cells with healthy cells cultured from stem cells is considered to potentially be a promising therapy for the treatment of stroke, neurodegenerative disorders and even brain tumors, but finding a reliable source for generating neural cells for transplantation has been a challenge. The use of embryonic and fetal tissue has raised ethical questions among some, and brings with it the possibility of immune rejection. And while neural stem cells can be taken from brain tissue, the removal of healthy tissue from a patient's brain introduces a new set of safety, practicality and ethical issues.
In their recent work, the Cedars-Sinai researchers documented that several genes that speed up and control the proliferation process could be used to rapidly expand the supply of marrow-derived neural stem cells, writing in the article that "this novel method of expansion … may prove to be useful in the design of novel therapeutics for the treatment of brain disorders, including tumors."
Sandy Van | EurekAlert!
Plant escape from waterlogging
17.10.2017 | Christian-Albrechts-Universität zu Kiel
Study suggests oysters offer hot spot for reducing nutrient pollution
17.10.2017 | Virginia Institute of Marine Science
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
17.10.2017 | Life Sciences
17.10.2017 | Physics and Astronomy
17.10.2017 | Life Sciences