The metabolome is the complete complement of all small molecule chemicals (metabolites) found in or produced by an organism. By analogy, if the genome represents the blueprint of life, the metabolome represents the ingredients of life.
The scientists have catalogued and characterized 2,500 metabolites, 1,200 drugs and 3,500 food components that can be found in the human body.
The research is published in the journal Nucleic Acids Research.
The researchers believe that the results of their work represent the starting point for a new era in diagnosing and detecting diseases.
They believe that the Human Metabolome Project (HMP), which began in Canada in 2004, will have a more immediate impact on medicine and medical practices than the Human Genome Project, because the metabolome is far more sensitive to the body's health and physiology.
"Metabolites are the canaries of the genome," says Project Leader Dr. Wishart, professor of computing science and biological sciences at the University of Alberta and Principal Investigator at NRC, National Institute for Nanotechnology. "A single base change in our DNA can lead to a 100,000X change in metabolite levels."
This $7.5 Million project funded by Genome Canada through Genome Alberta, the Canada Foundation for Innovation (CFI), Alberta Ingenuity Centre for Machine Learning, and the University of Alberta will have far reaching benefits to patient care.
"The results of this research will have a significant impact on the diagnosis, prediction, prevention and monitoring of many genetic, infectious and environmental diseases," stated Dr. David Bailey, President and CEO of Genome Alberta.
The metabolome is exquisitely sensitive to what a person eats, where they live, the time of day, the time of year, their general health and even their mood. The HMP is aimed at allowing doctors to better diagnose and treat diseases.
"Most medical tests today are based on measuring metabolites in blood or urine," Wishart says. "Unfortunately, less than 1% of known metabolites are being used in routine clinical testing. If you can only see 1% of what's going on in the body, you're obviously going to miss a lot."
By measuring or acquiring chemical, biological and disease association data on all known human metabolites, the HMP Consortium, which consists of some 50 scientists based at the University of Alberta and the University of Calgary, has spent the past two and half years compiling the remaining 95% of all known metabolites in the human metabolome. Detailed information about each of the 2500 metabolites identified so far can be found on the Human Metabolome Database (HMDB) at http://www.hmdb.ca.
"With the data in the HMDB, anyone can find out what metabolites are associated with which diseases, what the normal and abnormal concentrations are, where the metabolites are found or what genes are associated with which metabolites," Wishart says.
"It's the first time that this sort of data has been compiled into one spot. By decoding the human metabolome, we can identify and diagnose hundreds of diseases in a matter of seconds at a cost of pennies," Wishart added.
Ryan Smith | EurekAlert!
Designer cells: artificial enzyme can activate a gene switch
22.05.2018 | Universität Basel
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
22.05.2018 | Life Sciences
22.05.2018 | Earth Sciences
22.05.2018 | Trade Fair News