Scientists identify gene that may indicate predisposition to schizophrenia
In a new study from The American Journal of Human Genetics, a research team lead by Xinzhi Zhao and Ruqi Tang (Shanghai Jiao Tong University) present evidence that genetic variation may indicate predisposition to schizophrenia.
Specifically, their findings identify the chitinase 3-like 1 gene as a potential schizophrenia-susceptibility gene and suggest that the genes involved in biological response to adverse conditions are likely linked to schizophrenia.
Analyzing two separate cohorts of Chinese patients with schizophrenia, the researchers observed a positive association between schizophrenia and genetic variations in the promoter region of the chitinase 3-like 1 (CHI3L1) gene, an association that was significant in both population-based and family-based investigations.
The CHI3L1 gene acts as a survival factor in response to adverse environments, countering various types of physiological stress, such as inflammation, nutrient deprivation, and oxygen deficiency, all of which may induce high expression of CHI3L1. The gene is located on chromosome 1q32.1, a region that has been previously shown to have a weak correlation to schizophrenia.
A number of environmental factors, including prenatal exposure to disease, have been reported as risk factors of schizophrenia. However, the researchers argue that sensitivity to environmental stressors varies widely among individuals, and “at least part of this variation may be genetic in origin and/or involve gene-environment factors,” they write.
Genetic variations that change the expression of CHI3L1 can influence key processes dependent on CHI3L1 levels, knocking out portions of the AKT-mediated signal pathway. The AKT-mediated signal pathway has been shown to be impaired in patients with schizophrenia, and antipsychotic medication may induce AKT activation, to compensate for the impairment. Additionally, activation of the inflammatory response has been observed in those with schizophrenia and other affective disorders.
“In conclusion, our findings identify CHI3L1 as a potential schizophrenia-susceptibility gene,” write the authors. “Our results . . . support the proposal that genes involved in biological response to adverse environmental conditions play roles in the predisposition
Suzanne Wu | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
Physicists in Garching observe novel quantum effect that limits the number of emitted photons.
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...