Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Transdermal vaccine effective in treating Alzheimer's disease in mouse model

24.01.2007
May offer promise of skin patch or cream for treating dementia

University of South Florida researchers report that a novel needle-free vaccine approach is effective and safe in clearing brain-damaging plaques from a mouse model of Alzheimer's disease. The transdermal, or across the skin, vaccination, may offer a simpler way of preventing or treating the devastating neurodegenerative disease with less likelihood of adverse immune reactions.

The study was published online this week in The Proceedings of the National Academy of Sciences.

"While many groups have shown vaccinating against the beta amyloid protein (Ab) can reduce Alzheimer's-like pathology including certain cognitive deficits, this study is the first to demonstrate that immunization using the skin may be an effective way to reduce Ab pathology," said senior study author Jun Tan, PhD, MD, director of the Neuroimmunology Laboratory at the Institute for Research in Psychiatry, USF Department of Psychiatry.

... more about:
»Alzheimer' »immune cell »treating

"The beauty is that something as simple and non-invasive as a skin patch could potentially be a promising therapy for Alzheimer's disease," said study coauthor Terrence Town, PhD.

The Alzheimer's vaccine works by triggering the immune system to recognize Ab -- a protein that abnormally builds up in the brains of Alzheimer's patients – as a foreign invader and attack it.

Previous research on an injectable Alzheimer's vaccine proven safe and effective in an animal model was suspended indefinitely when the initial clinical trial caused brain inflammation and death in a small percentage of patients. These serious side effects were secondary to an autoimmune reaction, which occurred when immune cells aggressively attacked the body's own proteins produced by the vaccine.

The USF researchers targeted the skin as the route of vaccine delivery in mice bred to develop age-related brain degeneration mimicking Alzheimer's. They found that transdermal immunization with Ab does not appear to trigger specific toxicities associated with past immunization strategies.

Specialized immune cells prevalent in the skin, called Langerhans, may direct the body's reaction to the vaccine toward a response that is beneficial instead of overly aggressive and ultimately harmful, Dr. Tan said.

The USF researchers plan to further test whether the transdermal vaccine can curb memory loss in Alzheimer's mice as well as reduce their "senile" plaque burden. "If those studies show clear cognitive benefits," Dr. Tan said, "we believe clinical trials to evaluate a beta amyloid skin patch or topical cream in patients with Alzheimer's would be warranted."

Anne DeLotto Baier | alfa
Further information:
http://www.health.usf.edu

Further reports about: Alzheimer' immune cell treating

More articles from Life Sciences:

nachricht Zap! Graphene is bad news for bacteria
23.05.2017 | Rice University

nachricht Discovery of an alga's 'dictionary of genes' could lead to advances in biofuels, medicine
23.05.2017 | University of California - Los Angeles

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Scientists propose synestia, a new type of planetary object

23.05.2017 | Physics and Astronomy

Zap! Graphene is bad news for bacteria

23.05.2017 | Life Sciences

Medical gamma-ray camera is now palm-sized

23.05.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>