Research in the field of cellular technologies can lead to a new understanding of the development and differentiation of cells: their ability to transform into various types of cells and fabrics. In case of illness or wound stem cells can be used to restore or replace damaged fabric.
However, to achieve successful results of transplantation and treatment of such significant diseases as Parkinson's disease, Alzheimer's disease, leukemia, diabetes, stroke, muscular dystrophy, hepatic and renal failure etc., optimum methods have to be developed to obtain stem cells and their cultivation. Such a problem is successfully solved by scientists from Kazakhstan - employees of the Research-and-production enterprise "Antigen" under the direction of Project Manager Kaulambaeva Marzhan Zakanovna, head of the "Celluar cultures and culture medium” department. The research is supported actively by the International Science and Technology Center.
The final goal of the project is the creation of a hemopoietic stem cell bank collated from the marrow of an adult and the blood of newborn babies’ umbilical cords. Such a bank has a number of advantages compared with a bank of umbilical cord blood of newborn children and a bank of possible marrow donors. "First of all, during cell cultivation in vitro the concentration of the stem cells in the transplantant increases, thus increasing its biological value,” says Project Manager and Candidate of Biology Kaulambaeva Marzhan Zakanovna. “Secondly, during stem cell cultivation their antigenic properties decrease. Thus the degree of compatibility of donor stem cells and recipients increase, allowing us to avoid graft rejection by the organism, a frequent problem in the bone marrow transplantation of an adult. Thirdly, possessing a sample of stem cells, it is possible to easily restore and, upon subsequent cultivation to accumulate their reserve, if required for a constantly "a renewed material".
The unique opportunity to collect samples of cells from the various ethnic minorities living within Kazakhstan, undoubtedly raises the value of such a stem cell bank, and, if necessary, it will be possible to deliver cells in any country of the world at the request of any marrow transplantation center.
The project consists of three basic stages. At the initial stage we gather umbilical cord blood. It is established, that if the period of time from the moment of birth to the separation of a newborn child from the placenta is no more than 30 seconds the collected volume of blood, on average, is 25-40ml more than at later separation. The early separation of the child from the placenta has no negative consequences for the newborn. Containers for gathering blood are filled with special preservatives and anticoagulants. The second stage involves checking samples for sterility, in other words checking for the presence of microorganisms or viruses with the application of various nutrient mediums and the polymer chain reaction method. At the final stage cryoconservation of stem cells is performed for long-term storage. During cryoconservation optimum conditions will be developed for long-term storage of stem cells of marrow and blood of newborn children’s umbilical cords with the application of various concentrations of cryoprotectors.
Successful realization of each stage is the guarantee of successfully obtaining stem cells, their cultivation, and their subsequent application, and the developed techniques will be able to successfully combat diseases that are currently considered incurable.
Olga Radkevich | alfa
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Second research flight into zero gravity
21.10.2016 | Universität Zürich
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences