Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

There goes the neighborhood: Vascular niche nurtures brain tumor stem cells

18.01.2007
Self-renewing cancer stem cells (CSCs) comprise only a tiny fraction of most brain tumors, but eliminating them is likely to have a profound impact on the ability of a tumor to survive and grow. However, CSCs might resist traditional therapies that target the great bulk of the cells in cancers.

Now, new research published in the January 2007 issue of the journal Cancer Cell, published by Cell Press, reveals that small blood vessels associated with brain tumors orchestrate a distinct microenvironment that is critical for maintaining CSCs. Importantly, antiangiogenic drugs that disrupt this microenvironment reduce the CSC population and arrest tumor growth.

Dr. Richard J. Gilbertson and colleagues from the St. Jude Children's Research Hospital established that CSCs in human brain tumors are associated with blood vessels and that vascular cells physically interact with and maintain brain CSCs in culture. A similar interaction was not observed for the bulk of non-CSC tumor cells. To examine whether the vessel-derived factors promote maintenance of CSCs and tumor propagation in vivo, the researchers transplanted human brain tumors into mice with or without vascular cells. The mice with extra vascular cells exhibited an increase in CSCs as well as enhanced initiation and proliferation of tumors. The authors also found that when antiangiogenic therapies were used to diminish tumor blood vessels, CSCs were reduced and tumor growth was arrested, further supporting the importance of the vascular microenvironment to CSCs.

"Our data identify a possible role for niche microenvironments in the maintenance of CSCs and identify a mechanism by which antiangiogenic drugs inhibit brain tumor growth," concludes Dr. Gilbertson. "If the notion that niches protect CSCs proves correct, then targeting these microenvironments could prove highly effective treatments of cancer." Further research and clinical trials are needed to investigate this important new mechanism associated with antiangiogenic cancer therapies. It seems likely that effective cancer treatments must target both the bulk of rapidly proliferating tumor cells and the smaller population of self-renewing CSCs.

Erin Doonan | EurekAlert!
Further information:
http://www.cancercell.org

Further reports about: CSC antiangiogenic microenvironment niche vascular vascular cells

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>