Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bone-degrading substances also produced by gums’ own cells

16.01.2007
Our gums’ own cells produce the substances that lead to the degeneration of the jawbone. This is one of the findings in a dissertation that Py Palmqvist will defend at Umeå University in Sweden on January 19.

The findings are important to our understanding of how inflammation leads to loosening of the teeth, arthritic rheumatism, and prostheses detaching from the body.

The dissertation shows that certain signal substances in the body, so-called cytokines, have the ability to stimulate the cells in bones to degenerate and that these cytokines are produced not only by white blood corpuscles but also by cells in the gums, so-called gum fibroblasts. The production of the cytokine interleukin-6 and its closest relatives, interleukin-11 and leukemia inhibitory factor, is stimulated by certain inflammatory cytokines and is inhibited by other anti-inflammatory cytokines from white blood corpuscles. The findings are important to our understanding of the interplay between local cells in the gums and white blood corpuscles immigrating from the blood that regulates the degradation of bone in diseases involving loosening of the teeth.

The skeleton of a healthy adult human is constantly being renewed, with some parts degrading and being replaced by new bone, on the one hand, to exchange old bone for new bone and, on the other hand, to adapt the structure of the bone to new loads. This occurs at a rate of about 10 percent of the entire bone tissue being replaced each year. In pathological conditions, the reconstruction process can be altered so that the degradation increases and the new growth cannot replace all the degenerated bone. This occurs, for example, in most of the bones in the bodies of patients afflicted with osteoporosis as a result of changes in the amounts of sex hormones. It also occurs locally in certain parts of the skeleton where inflammatory processes are underway. In patients with inflamed gums, the inflammation process can affect the replacement of the bone around the teeth in the jaws so that the bone is lost. The teeth will then become looser and looser until they fall out­gum inflammation has led to loosening of the teeth.

... more about:
»Cytokine »GUM »inflammation »loosening

In the same way, in patients with arthritic rheumatism, an inflammation can cause the bone in the joint to be lost, leaving the patient with pain and more and more limited joint function. Inflammation is also the cause of the loosening of certain implants in joints and in the skeleton.

The findings are significant for our understanding of how inflammation processes lead to the degradation of bone in diseases involving loosening of the teeth, arthritic rheumatism, and the loosening of prostheses in the skeleton.

Bertil Born | alfa
Further information:
http://www.diva-portal.org/umu/theses/abstract.xsql?dbid=960&lang=sv

Further reports about: Cytokine GUM inflammation loosening

More articles from Life Sciences:

nachricht Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg

nachricht Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>