Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Novel preparation techniques for cardiac glycosides

12.01.2007
The flora of the Earth is a huge inexhaustible “well” of remedies. There are over 12,000 species of medicinal plants and they have been used to treat many different illnesses for several thousands of years. However, using only herbal infusions is not enough to achieve a curative positive effect, medicines have to be obtained from vegetable raw materials and knowledge is required on the mechanism of its action.

For example, to prepare the highly active cardiovascular medication digoxin effective methods have to be developed to extract medicinal substances – glycosides. Such a problem is solved successfully by scientists from the State Research Institute of Organic Chemistry and Technology under the direction of the Project Manager Galina Mikhailovna Komissarova. The International Science and Technology Centre supports the scientific research.

During a 200-year history of the application of cardiac glycosides in medical practice views on the mechanism of their action and the methods of obtaining the medications of the series of cardiotonic glycosides have changed considerably. But one thing remains unchanged – the application of cardiac glycosides at the initial or latent stage of heart failure can correct available functional cardiac abnormalities and prevent the development of obvious heart failure.

A number of patented methods of preparing digoxin from Digitalis lanata with the use of natural enzymes are presently available. However, these patented methods have a number of major shortcomings. “The most essential among them, - says Galina Mikhailovna Komissarova, - is low stability of the fermentation process owing to the quality of herbal raw materials”. Secondly, toxic and explosive solvents, which are costly materials, are used in these methods. Besides, a great number of technological purification stages have to be performed to obtain the final medication; this is a very laborious process.

... more about:
»cardiac »digoxin »glycosides

During project realization the developers from the State Scientific Centre “State Research Institute of Organic Chemistry and Technology” succeeded in avoiding all of the above shortcomings, owing to totally new techniques of growing, picking, drying and storing Digitalis lanata. The obtained plant raw materials are characterized by a stably high content of highly active enzymes. The technique of preparing digoxin by means of enzymatic degradation in aqueous media at 45oC was elaborated, with the process proceeding completely without hindrance to the subsequent extraction and cleaning stages.

The advantages of the proposed method are controlled standard conditions in aqueous media during the formation of digoxin and the modification of conventional stages of digoxin extraction.

The novelty and uniqueness of the proposed Project is that it proposes a method for controlling the activity of enzymes in the raw material; it is designed to facilitate the production of a protein concentrate with certain enzymatic activity, and examination of activity standards required for effectively performing the raw material fermentation stage in the production of digoxin. Using novel techniques, the developers have managed to obtain a test sample – 50 grams of digoxin. In future it is planned to modernize the extraction and purification methods of cardiotonic glycosides and methods of analytical production control that will help to provide medical organizations with the necessary quantity of this medication and it will give people the chance to recover from this serious illness.

Olga Radkevich | alfa
Further information:
http://tech-db.istc.ru/istc/sc.nsf/events/cardiac-glycosides

Further reports about: cardiac digoxin glycosides

More articles from Life Sciences:

nachricht Topologische Quantenchemie
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

nachricht Topological Quantum Chemistry
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

Ultrathin device harvests electricity from human motion

24.07.2017 | Power and Electrical Engineering

Scientists announce the quest for high-index materials

24.07.2017 | Materials Sciences

ADIR Project: Lasers Recover Valuable Materials

24.07.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>