For example, to prepare the highly active cardiovascular medication digoxin effective methods have to be developed to extract medicinal substances – glycosides. Such a problem is solved successfully by scientists from the State Research Institute of Organic Chemistry and Technology under the direction of the Project Manager Galina Mikhailovna Komissarova. The International Science and Technology Centre supports the scientific research.
During a 200-year history of the application of cardiac glycosides in medical practice views on the mechanism of their action and the methods of obtaining the medications of the series of cardiotonic glycosides have changed considerably. But one thing remains unchanged – the application of cardiac glycosides at the initial or latent stage of heart failure can correct available functional cardiac abnormalities and prevent the development of obvious heart failure.
A number of patented methods of preparing digoxin from Digitalis lanata with the use of natural enzymes are presently available. However, these patented methods have a number of major shortcomings. “The most essential among them, - says Galina Mikhailovna Komissarova, - is low stability of the fermentation process owing to the quality of herbal raw materials”. Secondly, toxic and explosive solvents, which are costly materials, are used in these methods. Besides, a great number of technological purification stages have to be performed to obtain the final medication; this is a very laborious process.
During project realization the developers from the State Scientific Centre “State Research Institute of Organic Chemistry and Technology” succeeded in avoiding all of the above shortcomings, owing to totally new techniques of growing, picking, drying and storing Digitalis lanata. The obtained plant raw materials are characterized by a stably high content of highly active enzymes. The technique of preparing digoxin by means of enzymatic degradation in aqueous media at 45oC was elaborated, with the process proceeding completely without hindrance to the subsequent extraction and cleaning stages.
The advantages of the proposed method are controlled standard conditions in aqueous media during the formation of digoxin and the modification of conventional stages of digoxin extraction.
The novelty and uniqueness of the proposed Project is that it proposes a method for controlling the activity of enzymes in the raw material; it is designed to facilitate the production of a protein concentrate with certain enzymatic activity, and examination of activity standards required for effectively performing the raw material fermentation stage in the production of digoxin. Using novel techniques, the developers have managed to obtain a test sample – 50 grams of digoxin. In future it is planned to modernize the extraction and purification methods of cardiotonic glycosides and methods of analytical production control that will help to provide medical organizations with the necessary quantity of this medication and it will give people the chance to recover from this serious illness.
Olga Radkevich | alfa
Flavins keep a handy helper in their pocket
25.04.2018 | University of Freiburg
Complete skin regeneration system of fish unraveled
24.04.2018 | Tokyo Institute of Technology
At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.
Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
25.04.2018 | Physics and Astronomy
25.04.2018 | Physics and Astronomy
25.04.2018 | Information Technology