The project, funded through the European Commission’s 6th Framework Programme, sets the stage for an open-access resource of binding molecules directed against the entire human proteome, the full set of over 100,000 proteins specified by the human genome.
Established with initial funding of €1.8 M over 4 years, ‘ProteomeBinders’ is co-ordinated by Dr Mike Taussig, Head of the Technology Research Group at the Babraham Institute, and brings together 26 European partners from 12 countries, and two from the USA.
A major challenge of the post-genomic era is to understand how the information encoded within the genome, and expressed as the proteome, choreographs the biological organisation of cells, tissues and organisms. “This requires a comprehensive, standardised collection of specific protein-binding molecules. ‘ProteomeBinders’ aims to provide the tools required to detect and characterise all the relevant human proteins in tissues and fluids in health and disease,” commented Mike Taussig. Currently, antibodies are the most widely used protein-binders, but novel binder types based on alternative protein scaffolds, nucleic acids, peptides and chemical entities each have significant advantages and will be evaluated through this collaboration.
Currently there is no pan-European platform for the systematic development and quality control for these essential reagents. The ‘ProteomeBinders’ consortium will coordinate a new European resource, by integrating existing infrastructures, reviewing technologies and high-throughput production methods, standardising tools and applications, and establishing a database.
As one of the largest genome-scale projects in Europe, aiming ultimately to produce and collect hundreds of thousands of specific binders, this resource brings benefits to basic and applied research. The resource will impact on healthcare, diagnostics, target discovery for drug intervention and therapeutics, and will consequently deliver advantages to the research, medical and biotechnology communities.Contact details:
More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
19.01.2018 | Materials Sciences
19.01.2018 | Health and Medicine
19.01.2018 | Physics and Astronomy