In the study, scientists followed 3209 participants in the Framingham Heart Study for 10 years and measured 10 of the most promising ‘novel’ biomarkers for predicting the risk of cardiovascular disease (CVD). The newer biomarkers such as natriuretic peptides, C-reactive protein, fibrinogen, urinary albumin, and homocysteine were compared with established risk factors such as high blood pressure, diabetes, and high cholesterol.
Measuring several biomarkers simultaneously, referred to as the "multimarker" approach, enabled the scientists to stratify risk. They found that persons with high multimarker scores had a risk of death four times as great and a risk of major cardiovascular events almost two times as great as persons with low multimarker scores. However, the use of multiple biomarkers added only moderately to the overall prediction of risk based on conventional risk factors.
"Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death," was funded by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health. Daniel Levy, M.D., Director of the Framingham Heart Study, is available to comment on the study’s affirmation of the importance of traditional risk factors. He can also discuss the promise of new biomarkers --despite their modest enhancement over conventional risk factors-- in identifying individuals at high risk for cardiovascular events. In addition, Levy can comment on NHLBI’s recently announced large-scale biomarker project, a proposed biomarker consortium to conduct research on novel CVD biomarkers and develop new diagnostic tests to identify individuals at high risk for CVD and its risk factors.
NHLBI Communications Office | EurekAlert!
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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