Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Oxymetazoline as an anti-inflammatory drug in nose sprays: Mode of action now clear

21.12.2006
Scientists from the GSF – Research Center for Environment and Health in Neuherberg near Munich have shown how oxymetazoline inhibits inflammation. The active ingredient in nose sprays has so far mainly been known as a substance reducing the swelling of the mucous membrane.

The GSF experts have now elucidated the exact mechanism of an anti-inflammatory effect. This is an important contribution by the GSF to the transfer of knowledge from fundamental research to practical application.

When a patient has a cold (rhinitis), the body reacts to a viral infection by showing inflammatory reactions. Oxymetazoline interferes with this process in different ways: on the one hand it inhibits the enzyme 5-lipoxygenase, which is involved in the production of proinflammatory substances – so-called leukotrienes. The scientists from the GSF Institute of Inhalation Biology have shown this in vitro, i.e. in cell-free systems, and in body cells from lung tissue (alveolar macrophages). On the other hand oxymetazoline reduces the oxidative stress due to inflammatory reactions accompanying a cold, which damages the cells. This was shown by the scientists using stress marker substances in the alveolar macrophages.

The effects mentioned occurred even with relatively low concentrations, which – as the scientists think – are achieved by nose sprays. Preliminary studies had shown that high doses of oxymetazoline can inhibit inflammation. The exact mechanisms, however, were not yet known.

“The special feature of the mode of action is that proinflammatory processes are inhibited, but anti-inflammatory processes are not influenced,” says Dr. Ingrid Beck-Speier from the Institute of Inhalation Biology of the GSF. Thus, laboratory experiments have shown that 15-lipoxygenase is not inhibited. This is an enzyme involved in the production of anti-inflammatory substances.

The GSF – Research Center for Environment and Health investigates the foundations of a medicine of the future for the development of new approaches in prevention, diagnosis and therapy. The aim is to closely link research and application. This is also what this research project, cofunded by Merck Selbstmedikation, stands for. Merck uses oxymetazoline in nose sprays.

Michael van den Heuvel | alfa
Further information:
http://www.gsf.de/neu/Aktuelles/Presse/2006/oxymetazolin_en.php

Further reports about: anti-inflammatory inhibit nose oxymetazoline sprays

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>