Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The virulence of the Toxoplasma parasite identified

15.12.2006
A research group led by Antonio Barragan of the Swedish Institute for Infectious Disease Control (SMI) and Karolinska Institutet (KI) has identified, with the help of colleagues from Washington University, the gene in the Toxoplasma parasite that accounts for its ability to cause disease.

What the scientists have located is the kinase (an enzyme) that seems to be the main virulence factor. The results are presented in the prestigious scientific journal Science.

Between 14 and 25 per cent of the population of Sweden, and between 25 and 50 per cent of the global population, are bearers of a chronic, dormant infection from the Toxoplasma parasite. This makes the parasite possibly the most common in the world. It exists in our natural environment and is transferred into people through food, dirty water or contact with cats.

A healthy person who becomes infected with the parasite can develop influenza-like symptoms; it can then become dormant, making these people life-long carriers. However, for a person with weakened immune defence, such as someone with HIV/AIDS, an organ recipient or a cancer patient, the infection can prove life-threatening. An infection during pregnancy can also have serious consequences for the foetus.

... more about:
»Toxoplasma »parasite

The scientists have found that parasites that exist in the environment or in chronically infected individuals carry either a ”benign” (non-virulent) or a malignant (virulent) variant of the identified gene. The studies carried out in the SMI’s laboratories show that when the virulent variant of the gene is transferred to a benign parasite it leads to a 100 per cent lethal infection in mice; in other words, the formerly benign parasite becomes highly virulent.

The group believes that their findings will be of decisive importance for vaccine development and the diagnosis and treatment of serious Toxoplasma infection.

The article is published “back to back” with a scientific article from Stanford University, where a group of scientists have arrived independently at exactly the same results, something that is very rare in the world of research.

Katarina Sternudd | alfa
Further information:
http://ki.se

Further reports about: Toxoplasma parasite

More articles from Life Sciences:

nachricht When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short
23.03.2017 | Institut für Pflanzenbiochemie

nachricht WPI team grows heart tissue on spinach leaves
23.03.2017 | Worcester Polytechnic Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

Inactivate vaccines faster and more effectively using electron beams

23.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>