Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New biomarker predicts effectiveness of breast cancer drugs

11.12.2006
University of Cincinnati (UC) researchers have identified a new way to predict when anti-estrogen drug therapies are inappropriate for patients with hormone-dependent breast cancer.

The team’s leader, Erik Knudsen, PhD, says the findings could help physicians more accurately predict which tumors will respond to anti-estrogen therapy and improve long-term survival for breast cancer patients.

“If we know upfront that a patient’s cancer will resist traditional anti-estrogen therapies,” Knudsen says, “physicians can immediately begin treating the patient with alternative drugs that are more likely to succeed.”

The UC researchers found that when a pathway controlling cell growth known as the retinoblastoma (RB) tumor suppressor is disrupted or “shut off,” the tumor resists anti-estrogen drugs and the cancer continues to grow in spite of the therapy. They report their findings in the January edition of the Journal of Clinical Investigation.

... more about:
»Knudsen »anti-estrogen »breast »breast cancer

Anti-estrogen drugs such as tamoxifen (Novaldex) are a standard treatment for hormone-dependent breast cancer. They work by blocking the estrogen action, which is required for the proliferation of most breast cancers. Although these drugs are effective in the beginning, says Knudsen, many patients who initially respond to this treatment eventually develop a resistance to it.

“Since evidence shows anti-estrogen drugs will fail in a many patients with estrogen-receptor-positive breast cancer,” says Knudsen, “our research suggests that physicians should examine both estrogen receptor status and RB tumor suppressor status during the initial diagnosis, in order to prescribe the most effective therapy for that specific patient’s cancer.”

According to the National Cancer Institute, about two-thirds of women with breast cancer have estrogen-receptor-positive breast cancer, in which tumor growth is regulated by the natural female hormone estrogen. Previous research has shown that estrogen promotes the growth of most types of breast cancer.

“The RB tumor suppressor is a fundamental regulator of cell proliferation in the body, so we can use its actions as a biomarker for how tumors will respond to anti-estrogen therapy,” explains Knudsen. “It could become the basis for deciding how patients with estrogen-receptor-positive breast cancer are treated clinically.”

In this one-year laboratory study, Knudsen and his team used a specialized technique to disrupt the RB suppression pathway in breast cancer cells and analyzed the impact on tumor growth using animal models. The researchers then compared their results with a large patient record database to determine if the same phenomenon was occurring in patients with estrogen receptor-positive breast cancer. Studies supported their hypothesis that RB may be a critical determinant of whether a tumor will respond to anti-estrogen therapy.

Knudsen stresses that comprehensive clinical research is needed before this new method for predicting the success of anti-estrogen drugs is applied in daily patient care.

Amanda Harper | EurekAlert!
Further information:
http://www.uc.edu

Further reports about: Knudsen anti-estrogen breast breast cancer

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>