Researchers from major pharmaceuticals, Swiss-based computational biology firm Genedata and European Commission (EC) representatives met recently in Dublin for the Second General Assembly of InnoMed PredTox consortium. InnoMed PredTox is a joint Industry, Academic and EC collaboration to improve drug safety testing.
Tasked with exploring the molecular basis of drug-side effects, InnoMed PredTox is an ambitious project involving leading European pharmaceutical companies, academic research institutes and Genedata.
The gathering in Dublin met for an update on general progress over the last nine months and to discuss the consortium’s newly launched central data sharing portal. Biomolecular data from more than 20 laboratories is fed into a joint database, which is based on Genedata’s Expressionist platform.
Researchers use the portal via a secure Internet connection and have begun to share data and experimental design information. “The portal is critical for the management of the project’s progress”, said Dr. Laura Suter-Dick, Section Head for New Technologies in Safety, Roche.
Progress has been rapid, especially considering that the project involves cooperation between 20 independent research organizations. Earlier this year, members of the consortium met for an intensive planning session at Genedata’s headquarters in Basel. They agreed on critical design aspects of the database and on a sophisticated data analysis plan.
The InnoMed PredTox collaboration with Genedata is laying the foundation for toxicology to exploit genome-wide biological data in drug development. Genechip microarrays, 2D-gel and mass spectromerty experimental data is combined with conventional toxicology findings and clinical chemistry data. “Genedata is proud of the central place it occupies in InnoMed’s computational activities”, explained Dr. Othmar Pfannes, CEO of Genedata.
The InnoMed PredTox Second General Assembly was hosted by the Conway Institute (UCD), Dublin, Ireland, October 10th-11th, 2006. The InnoMed PredTox project is supported by partial funding under the Sixt Research Framework Programme of the European Union (LSHB-CT-2005-518170).
tobe freeman | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.
Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
New technique promises tunable laser devices
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...