The research, led by Linda H. Malkas, Ph.D., Vera Bradley Professor of Oncology and professor of medicine, and Robert J. Hickey, Ph.D., associate professor of medicine, involves a protein, PCNA, that plays a vital role in the processes that control cell replication, repair and death. The research team identified an antibody that can differentiate between the normal form of PCNA and the altered form found in breast cancer cells, Dr. Malkas said.
"That version, or isoform, of PCNA appears to be expressed uniquely in malignant breast cells, and the antibody we developed is the first to recognize that isoform, and so is good for differentiating malignant from non-malignant cells," said Dr. Malkas.
The research is being published in the Proceedings of the National Academy of Sciences Online Early Edition for the week of Dec. 4-8, 2006.
Despite educational efforts and improved diagnostic and treatment tools, more than 40,000 women die of breast cancer each year, Dr. Malkas noted. As a result, there is great interest in techniques that could enable earlier, reliable detection of cancer in its early stages, and to discover malignant cells left after cancer treatment.
The article notes that the antibody discovered by the IU scientists may be useful in the future in a variety of ways, such as screening for early stage cancers, monitoring patients whose cancer is in remission, identifying patients at higher risk of relapse or having their cancer spread, or in imaging systems to identify the locations of tumors in the body.
Dr. Malkas said that initial tests have found the altered form of the PCNA protein in other types of cancer as well, including esophageal, colon, neuroblastoma and ovarian cancers.
Cindy Fox Aisen | EurekAlert!
Modern genetic sequencing tools give clearer picture of how corals are related
17.08.2017 | University of Washington
The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
17.08.2017 | Physics and Astronomy
17.08.2017 | Earth Sciences
17.08.2017 | Physics and Astronomy