Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists work to identify genes that contribute to early heart attack risk

01.12.2006
Scientists at Wake Forest University Baptist Medical Center and colleagues at four other medical centers have launched a $10 million multi-year study to identify genes that may contribute to early atherosclerosis.

"If we can identify people in their teens and early adult life who have a genetic predisposition to develop atherosclerosis, we can manage their risk factors for heart disease and stroke sooner and more aggressively," said David Herrington, M.D., M.H.S., professor of cardiology at Wake Forest and lead investigator.

Other participating centers are Cedars Sinai Medical Center, Louisiana State University (LSU) Health Sciences Center in New Orleans, the University of Texas Health Science Center at Houston and the University of Washington.

Funded by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health, the study, known as SEA (SNPs and Extent of Atherosclerosis), will build on research from two previously funded NHLBI projects. The study will also benefit from a unique collaboration with Perlegen Sciences Inc., a company that specializes in techniques to uncover the genetic causes of diseases.

... more about:
»Health »atherosclerosis »genetic variant

Atherosclerosis is the development of fatty deposits in arteries that leads to blood clot formation, angina, heart attack and stroke. This process can begin in childhood and early adult life. Doctors have known that genetic factors contribute to risk for early atherosclerosis but the exact genes involved are not yet known.

"We hope the SEA study will give us new understanding about the causes of atherosclerosis, including the discovery of new genes and new pathways that could guide the development of new drug treatments that may be more effective in preventing the development of heart disease," said Herrington.

The researchers will take advantage of data from two large-scale studies: LSU Health Sciences Center’s Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study and the Multi-Ethnic Study of Atherosclerosis (MESA).

Using DNA data from the PDAY study, the scientists will work to pinpoint specific atherosclerosis genes. This autopsy study included about 3,000 young people, ages 15 to 34, who died from accidental causes, suicide and homicide. This study, which started in 1985, provided some of the best evidence that the process of atherosclerosis begins in childhood and adolescence. Using the latest technology, scientists will screen tissue samples from the study looking for genetic variants that may predispose individuals to develop early atherosclerosis.

"Perhaps the most remarkable thing about this study is the large number of genetic variants that we’re going to study," said Herrington. "Using special technology provided by Perlegen Sciences, we will examine more than 2 million different gene variations."

In part two of the study, the scientists will work to confirm their findings by determining if any genetic factors associated with early atherosclerosis in PDAY subjects also predict atherosclerosis in living participants of the $68 million MESA study. This 10-year multi-center study began in 2000 and is working to find new ways to detect heart disease before any symptoms occur.

The MESA study examined about 6,800 men and women, ages 45 to 84, who had no known heart disease. These participants were screened for atherosclerosis using non-invasive imaging tests. There are six study sites, including Wake Forest.

The researchers said it will take about five years to complete the SEA study.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

Further reports about: Health atherosclerosis genetic variant

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>