Cell therapy may be successful, but the added tissue performs worse than the orginal. PhD student Jeanine Hendriks of UT’s Institute for Biomedical Technology (BMTI) has developed a better method. She adds primary cells, still ‘knowing’ how to form a cartilage matrix, to the cultured cells. This seems to be a promising technique for improving cell therapy results.
Cartilage has unique properties, thanks to a matrix of cells.
The ‘proteoglycanes’ within this matrix are capable of binding water: if cartilage is under pressure, this water is squeezed out, does pressure get lower again, the water is bound again as well. This improves the flexibility of cartilage substantially, and is one of its unique features. In existing cell therapy, cells from a biopt are cultured for some three weeks. After that, the cells are injected underneath a piece of cell membrane, and the defect is repaired. The cells form cartilage tissue.
In clinical practice, this works, although the cells aren’t able to form the desired matrix structures: ‘they don’t know how to do that’. Jeanine Hendriks therefore investigated the possibilities of stimulating the cells to form a matrix. By mixing cultured cells with primary chrondocytes that haven’t been cultured yet, she is able to control the process. By allowing the primary and cultured cells to interact, a matrix will be formed. This is more than creating a more ideal growth environment. It is the cell-to-cell interaction that ‘does the trick’, according to Hendriks.
Tissue engineering in vivo
Her results are the starting point for a novel clinical procedure. Hendriks wants to seed the cells on a carrier, a so-called scaffold. This is the same technique that is used in tissue engineering, the main difference is that Hendriks wants to implant the scaffold immediately after seeding and let them grow in vivo, while in tissue engineering, cells usually are cultured in vitro.
The new technique is truly promising: after finishing her PhD work, Jeanine Hendriks wants to further develop the clinical procedures, within her own company CellCoTec.
Wiebe van der Veen | alfa
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine