Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Improved cell therapy for cartilage repair

30.11.2006
Artificially cultured cartilage cells, grown outside of the body for reparing damaged tissue, prove to be different from original cartilage tissue.

Cell therapy may be successful, but the added tissue performs worse than the orginal. PhD student Jeanine Hendriks of UT’s Institute for Biomedical Technology (BMTI) has developed a better method. She adds primary cells, still ‘knowing’ how to form a cartilage matrix, to the cultured cells. This seems to be a promising technique for improving cell therapy results.

Cartilage has unique properties, thanks to a matrix of cells.

The ‘proteoglycanes’ within this matrix are capable of binding water: if cartilage is under pressure, this water is squeezed out, does pressure get lower again, the water is bound again as well. This improves the flexibility of cartilage substantially, and is one of its unique features. In existing cell therapy, cells from a biopt are cultured for some three weeks. After that, the cells are injected underneath a piece of cell membrane, and the defect is repaired. The cells form cartilage tissue.

... more about:
»Hendriks »Matrix »cartilage »cultured

Cell-to-Cell interaction

In clinical practice, this works, although the cells aren’t able to form the desired matrix structures: ‘they don’t know how to do that’. Jeanine Hendriks therefore investigated the possibilities of stimulating the cells to form a matrix. By mixing cultured cells with primary chrondocytes that haven’t been cultured yet, she is able to control the process. By allowing the primary and cultured cells to interact, a matrix will be formed. This is more than creating a more ideal growth environment. It is the cell-to-cell interaction that ‘does the trick’, according to Hendriks.

Tissue engineering in vivo

Her results are the starting point for a novel clinical procedure. Hendriks wants to seed the cells on a carrier, a so-called scaffold. This is the same technique that is used in tissue engineering, the main difference is that Hendriks wants to implant the scaffold immediately after seeding and let them grow in vivo, while in tissue engineering, cells usually are cultured in vitro.

The new technique is truly promising: after finishing her PhD work, Jeanine Hendriks wants to further develop the clinical procedures, within her own company CellCoTec.

Wiebe van der Veen | alfa
Further information:
http://www.utwente.nl/en

Further reports about: Hendriks Matrix cartilage cultured

More articles from Life Sciences:

nachricht Scientists unlock ability to generate new sensory hair cells
22.02.2017 | Brigham and Women's Hospital

nachricht New insights into the information processing of motor neurons
22.02.2017 | Max Planck Florida Institute for Neuroscience

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Microhotplates for a smart gas sensor

22.02.2017 | Power and Electrical Engineering

Scientists unlock ability to generate new sensory hair cells

22.02.2017 | Life Sciences

Prediction: More gas-giants will be found orbiting Sun-like stars

22.02.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>