Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Molecule against psoriasis

23.11.2006
A number of chronic diseases break out because the body attacks an imaginary enemy. A research group at the Norwegian University of Science and Technology (NTNU) has created a molecule that prevents our immune system from running wild.

When the body thinks it is under attack, it defends itself in the best way possible, for instance by starting a defence inflammation.

This reaction is highly appropriate if the enemy is an influenza virus or something else that actually needs to be fought. However, sometimes the body misinterprets the signals, and starts a defence inflammation against a non-existent enemy.

The result could be so-called autoimmune diseases: psoriasis, arthritis, Bechterew’s, asthma, allergies, ulcerative colitis, multiple sclerosis, Crohn’s disease – and numerous others.

... more about:
»Disease »Psoriasis

The list is longer than we care to imagine, and affects large parts of the population.

“Judas enzyme” sends the wrong message

Professor Berit Johansen at the Department of Biology at NTNU previously discovered which enzyme that misinterprets signals and reprograms cells to divide much faster than they should – thus provoking disease.

The enzyme is called phospholipase A2, less formally known as the “Judas enzyme”.

Now, Professor Johansen and her research group have created various stop molecules that prevent the “Judas enzyme” from sending the wrong messages to the cell nucleus. By doing so, the inflammatory reaction can be prevented.

One of these stop molecules was recently tested in mice infected with psoriasis. The results are more than promising: Every single mouse got better, in all respects.

In addition, it turned out that a high dosage yielded better effect than a low dosage.

Medical testing right around the corner

This discovery means that a substantial part of the road to a new type of medication is history. The next step is testing on humans.

Early next year, the substance will be available as a cream, ready to be applied on the first test persons. This testing will take place in France.

Professor Berit Johansen’s new firm, Avexxin, is also testing out two other molecules, one against rheumatoid arthritis, and one against nephritis.

By Hege Tunstad and Lisa Olstad/Gemini Research Journal

Nina Tveter | alfa
Further information:
http://www.ntnu.no/indexe.php

Further reports about: Disease Psoriasis

More articles from Life Sciences:

nachricht For a chimpanzee, one good turn deserves another
27.06.2017 | Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPIMIS)

nachricht New method to rapidly map the 'social networks' of proteins
27.06.2017 | Salk Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Touch Displays WAY-AX and WAY-DX by WayCon

27.06.2017 | Power and Electrical Engineering

Drones that drive

27.06.2017 | Information Technology

Ultra-compact phase modulators based on graphene plasmons

27.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>