A newly described virus is not a cause of Kawasaki disease, according to an article by a group of researchers in Denver, Colorado. Their article appears in the Dec. 15 issue of The Journal of Infectious Diseases, now available online.
The cause or causes of Kawasaki disease, an important pediatric infection that may lead to heart disease, have long been elusive. A study published in The Journal of Infectious Diseases last year by Jeffrey S. Kahn, MD, and colleagues at Yale University suggested that Kawasaki disease was associated with a new human coronavirus – one of a family of viruses affecting the respiratory tract. As an accompanying editorial pointed out then, the association required confirmation by other investigators.
Prompted by the Yale findings, Samuel R. Dominguez, MD, PhD, and colleagues at the University of Colorado Health Science Center and The Children's Hospital in Denver conducted a case-control study comparing nasopharyngeal samples of pediatric patients to determine if infection with the new human coronavirus, also called coronavirus NL63, is associated with Kawasaki disease. They found it was not: The percentage of children infected with coronavirus NL63 was the same--7.7 percent--in children both with and without Kawasaki syndrome,.
As to why the new results diverged from those of Dr. Kahn, Dominguez suggested one possibility could have been an inadvertent selection bias based on the samples available in the previous study. Of the 53 children identified with Kawasaki disease in the previous study, respiratory specimens were only available from 11 children.
Anne H. Rowley, MD, from Northwestern University Feinberg School of Medicine and The Children's Memorial Hospital in Chicago pointed out in an accompanying editorial other studies testing the association between coronaviruses and Kawasaki disease. The conclusions of these studies are similar to those of Dominguez et al, she said, and "it is now quite clear that the elusive etiological agent of Kawasaki disease is not the new human coronavirus."
Rowley commented that "finding the cause of Kawasaki disease is a pediatric infectious diseases research priority. Identification of the causative agent(s) would be the most promising step toward developing a diagnostic test and specific therapy, and ultimately preventing the disease."
Steve Baragona | EurekAlert!
When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short
23.03.2017 | Institut für Pflanzenbiochemie
WPI team grows heart tissue on spinach leaves
23.03.2017 | Worcester Polytechnic Institute
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
23.03.2017 | Life Sciences
23.03.2017 | Power and Electrical Engineering
23.03.2017 | Earth Sciences