A newly described virus is not a cause of Kawasaki disease, according to an article by a group of researchers in Denver, Colorado. Their article appears in the Dec. 15 issue of The Journal of Infectious Diseases, now available online.
The cause or causes of Kawasaki disease, an important pediatric infection that may lead to heart disease, have long been elusive. A study published in The Journal of Infectious Diseases last year by Jeffrey S. Kahn, MD, and colleagues at Yale University suggested that Kawasaki disease was associated with a new human coronavirus – one of a family of viruses affecting the respiratory tract. As an accompanying editorial pointed out then, the association required confirmation by other investigators.
Prompted by the Yale findings, Samuel R. Dominguez, MD, PhD, and colleagues at the University of Colorado Health Science Center and The Children's Hospital in Denver conducted a case-control study comparing nasopharyngeal samples of pediatric patients to determine if infection with the new human coronavirus, also called coronavirus NL63, is associated with Kawasaki disease. They found it was not: The percentage of children infected with coronavirus NL63 was the same--7.7 percent--in children both with and without Kawasaki syndrome,.
As to why the new results diverged from those of Dr. Kahn, Dominguez suggested one possibility could have been an inadvertent selection bias based on the samples available in the previous study. Of the 53 children identified with Kawasaki disease in the previous study, respiratory specimens were only available from 11 children.
Anne H. Rowley, MD, from Northwestern University Feinberg School of Medicine and The Children's Memorial Hospital in Chicago pointed out in an accompanying editorial other studies testing the association between coronaviruses and Kawasaki disease. The conclusions of these studies are similar to those of Dominguez et al, she said, and "it is now quite clear that the elusive etiological agent of Kawasaki disease is not the new human coronavirus."
Rowley commented that "finding the cause of Kawasaki disease is a pediatric infectious diseases research priority. Identification of the causative agent(s) would be the most promising step toward developing a diagnostic test and specific therapy, and ultimately preventing the disease."
Steve Baragona | EurekAlert!
Zap! Graphene is bad news for bacteria
23.05.2017 | Rice University
Discovery of an alga's 'dictionary of genes' could lead to advances in biofuels, medicine
23.05.2017 | University of California - Los Angeles
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
23.05.2017 | Event News
22.05.2017 | Event News
17.05.2017 | Event News
23.05.2017 | Physics and Astronomy
23.05.2017 | Life Sciences
23.05.2017 | Medical Engineering