Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Newly Adult-born Neurons Are Functionally Similar to Mature Neurons

21.11.2006
Adult neurogenesis produces neurons with similar functional properties to mature neurons in the hippocampus of mice

In mammals, the production of new brain cells occurs primarily at the time the nervous system is developing, although certain brain areas generate neurons throughout adulthood. One such area is the hippocampus, a part of the brain involved in the critical function of memory and spatial perception. Hippocampal cells, specifically dentate granule cells, are continuously produced in adults as well as in young animals.

How these “adult-born” cells build their connections with the rest of the brain, and the extent to which they resemble “pup-born” cells, is of great interest to those who would like to coax other parts of adult brains to make new cells as a strategy for reversing the loss of function from trauma or degenerative disorders. To find out whether adult-born hippocampal neurons have different properties than mature neurons that arose when the brain was developing, Diego Laplagne, Alejandro Schinder, and colleagues compared how each type of neuron incorporated functionally into brain circuits.

The researchers’ first task was to figure out a way to distinguish between pup-born and adult-born neurons in brain tissue that contained both. To accomplish that task, they used retroviruses to introduce one kind of fluorescent protein into the developing neurons and a second protein into the adult mouse brain. As a result of this treatment, the pup-born cells fluoresced green and the adult-born cells fluoresced red, making them readily distinguishable in brain slices.

... more about:
»Hippocampus »Neuron »adult-born »neurons »pup-born

Once they could tell the two types of cells apart, the researchers gained insight into the connections formed. They looked at glutamatergic (excitatory) nerves connecting the hippocampus with the entorhinal cortex, another brain area associated with memory. When they stimulated the excitatory inputs carrying information from the neocortex to the hippocampus, the researchers evoked similar responses in both pup-born and adult-born neurons. Moreover, both cell types responded in the same dynamic manner to the stimulation, suggesting their ability to undergo synaptic plasticity is similar. Next, the researchers looked at GABAergic (inhibitory) inputs from interneurons that connect to the body and dendrites of the hippocampal neurons. Again, they see the responses are similar in frequency, amplitude, and kinetics between the pup-born and adult-born cells.

Having shown that pup-born and adult-born neurons respond to both excitatory and inhibitory inputs in the same way, the researchers next turned their attention to how the two types of cells integrate the signals from the various inputs to produce an action potential, or spike (which leads to the communication of the signal to subsequent neurons). Spiking probability varied among neurons but was not distinguishable between the two cell types, further supporting the earlier indications that adult-born and pup-born neurons function in fundamentally the same way.

Given the functional similarities between adult-born and pup-born neurons, this means that at least some neurons that develop in adult brains can form connections that are indistinguishable from connections formed by neurons that develop early in life—a hopeful finding for those who have set their sights on one day being able to repair damaged or deteriorated brain tissue.

Citation: Laplagne DA, Espo´ sito MS, Piatti VC, Morgenstern NA, Zhao C, et al. (2006) Functional convergence of neurons generated in the developing and adult hippocampus. PLoS Biol 4(12): e409. DOI: 10.1371/journal.pbio.0040409.

Andrew Hyde | alfa
Further information:
http://www.plosbiology.org

Further reports about: Hippocampus Neuron adult-born neurons pup-born

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>