Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication

17.11.2006
As public health officials around the world keep a nervous eye on the spread of avian influenza, the University of Saskatchewan's Vaccine and Infectious Disease Organization (VIDO) has uncovered a key step in how the influenza virus causes infection.

Yan Zhou and her team have discovered how a crucial pathway that supports the influenza A virus's ability to reproduce itself is activated, a finding that could pave the way for new drugs and vaccines.

The paper will appear in the January 2007 issue of the Journal of General Virology and recently has been given advance on-line publication.

"The work we are doing will be applicable to all influenza viruses, including influenza A virus subtype H5N1," said VIDO Director Lorne Babiuk.

... more about:
»Influenza »Key »Virus »flu

Zhou says that although years of research remain to be done, this work provides novel insights for developing live vaccines and antiviral drugs for influenza epidemics and pandemics. A provisional patent has been filed on the findings.

"Given the health, economic and social consequences of influenza epidemics, the work of Dr. Zhou and her team demonstrates the importance of building influenza research capacity in Canada," said Dr. Bhagirath Singh, Scientific Director of the CIHR Institute of Infection and Immunity.

"Their research findings may help to develop new influenza treatments and prevent the disease, as well as add to global pandemic preparedness research."

To survive, the influenza virus hijacks the host animal or human's cellular machinery and forces it to make more copies of the virus. The researchers believe that the cellular events involved in this process are an excellent target for interventions against influenza.

The study revealed novel characteristics of a protein, called NS1, that activates a key pathway in the virus's reproduction. This information will help the researchers learn how to create harmless influenza viruses that can be used as live vaccines.

The pathway can be thought of as an assembly line with a switch to turn it on, says Zhou. "If the switch is turned on, the pathway enables efficient production of more viruses. But only the NS1 protein can turn on the switch."

The researchers are investigating genes and proteins of the influenza viruses of swine, horses and birds to see how they activate downstream cellular signalling pathways. To do this, they are using reverse genetics technology, where researchers begin with a gene and figure out its function.

These studies will allow the team to identify the genes that enable the virus to cause disease, laying the groundwork for antiviral drug development.

"Increasingly, new diseases involve both humans and animals," said Andrew Potter,VIDO's Associate Director (Research). "VIDO's background in veterinary research means that when diseases like avian influenza develop, we have the resources to begin studying the disease fairly quickly."

Marie-France Poirier | EurekAlert!
Further information:
http://www.cihr-irsc.gc.ca

Further reports about: Influenza Key Virus flu

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>