Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication

17.11.2006
As public health officials around the world keep a nervous eye on the spread of avian influenza, the University of Saskatchewan's Vaccine and Infectious Disease Organization (VIDO) has uncovered a key step in how the influenza virus causes infection.

Yan Zhou and her team have discovered how a crucial pathway that supports the influenza A virus's ability to reproduce itself is activated, a finding that could pave the way for new drugs and vaccines.

The paper will appear in the January 2007 issue of the Journal of General Virology and recently has been given advance on-line publication.

"The work we are doing will be applicable to all influenza viruses, including influenza A virus subtype H5N1," said VIDO Director Lorne Babiuk.

... more about:
»Influenza »Key »Virus »flu

Zhou says that although years of research remain to be done, this work provides novel insights for developing live vaccines and antiviral drugs for influenza epidemics and pandemics. A provisional patent has been filed on the findings.

"Given the health, economic and social consequences of influenza epidemics, the work of Dr. Zhou and her team demonstrates the importance of building influenza research capacity in Canada," said Dr. Bhagirath Singh, Scientific Director of the CIHR Institute of Infection and Immunity.

"Their research findings may help to develop new influenza treatments and prevent the disease, as well as add to global pandemic preparedness research."

To survive, the influenza virus hijacks the host animal or human's cellular machinery and forces it to make more copies of the virus. The researchers believe that the cellular events involved in this process are an excellent target for interventions against influenza.

The study revealed novel characteristics of a protein, called NS1, that activates a key pathway in the virus's reproduction. This information will help the researchers learn how to create harmless influenza viruses that can be used as live vaccines.

The pathway can be thought of as an assembly line with a switch to turn it on, says Zhou. "If the switch is turned on, the pathway enables efficient production of more viruses. But only the NS1 protein can turn on the switch."

The researchers are investigating genes and proteins of the influenza viruses of swine, horses and birds to see how they activate downstream cellular signalling pathways. To do this, they are using reverse genetics technology, where researchers begin with a gene and figure out its function.

These studies will allow the team to identify the genes that enable the virus to cause disease, laying the groundwork for antiviral drug development.

"Increasingly, new diseases involve both humans and animals," said Andrew Potter,VIDO's Associate Director (Research). "VIDO's background in veterinary research means that when diseases like avian influenza develop, we have the resources to begin studying the disease fairly quickly."

Marie-France Poirier | EurekAlert!
Further information:
http://www.cihr-irsc.gc.ca

Further reports about: Influenza Key Virus flu

More articles from Life Sciences:

nachricht Repairing damaged hearts with self-healing heart cells
22.08.2017 | National University Health System

nachricht Biochemical 'fingerprints' reveal diabetes progression
22.08.2017 | Umea University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>