Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fusing genes could hold leukaemia treatment clues

17.11.2006
Pioneering cancer scientists at The University of Nottingham are to investigate why a rare form of leukaemia is triggered when two genes fuse together.

It is hoped the research will lead to the discovery of potential new drugs to treat the rare form of acute myeloid leukaemia, which currently affects 2,000 adults and more than 100 children in the UK every year.

Professor David Heery and Dr Karin Kindle in the University’s School of Pharmacy have been awarded a £150,000 grant from the AICR (Association of International Cancer Research) to study how the abnormal fusion of MOZ and TIF2 genes affects bone marrow cells and, by doing so, contributes to the development of the cancer.

Professor Heery, head of the Division of Molecular and Cellular Sciences, said: “At least 50 genes have been identified that are involved in gene fusions associated with leukaemia. The key question is to discover how MOZ-TIF2 and similar fusion proteins affect cell function.

... more about:
»Treatment »affect »leukaemia

“This will be critical in the future discovery of potential new drug treatments for patients with this form of the disease.”

AICR’s scientific adviser Dr Mark Matfield believes the work will have important implications in better understanding a type of leukaemia for which the exact causes are, as yet, unknown.

“This is an aggressive form of cancer and although it can affect all ages it is more common in older people, with slightly more reported cases in men. The main lab tests used in diagnosis are a full blood count and bone marrow biopsy,” he said.

“Without treatment AML will rapidly cause death, but with modern treatment protocols the cure rate has improved significantly in patients who are under 60. Older people tend to do less well, partly because they are often unable to receive the very intensive therapy needed for effective management of the disease.”

Derek Napier, AICR’s Chief Executive, said the grant was in line with the charity’s policy of funding the most exciting and novel approaches to research worldwide.

“We believe it important to fund work that pushes the boundaries and Professor Heery and Dr Kindle are charged with tackling a great scientific challenge that could in future change the lives of tens of thousands of people in the UK across the world.”

Emma Thorne | alfa
Further information:
http://www.nottingham.ac.uk

Further reports about: Treatment affect leukaemia

More articles from Life Sciences:

nachricht What happens in the cell nucleus after fertilization
06.12.2016 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Robot on demand: Mobile machining of aircraft components with high precision

06.12.2016 | Power and Electrical Engineering

A new dead zone in the Indian Ocean could impact future marine nutrient balance

06.12.2016 | Earth Sciences

Significantly more productivity in USP lasers

06.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>