It is hoped the research will lead to the discovery of potential new drugs to treat the rare form of acute myeloid leukaemia, which currently affects 2,000 adults and more than 100 children in the UK every year.
Professor David Heery and Dr Karin Kindle in the University’s School of Pharmacy have been awarded a £150,000 grant from the AICR (Association of International Cancer Research) to study how the abnormal fusion of MOZ and TIF2 genes affects bone marrow cells and, by doing so, contributes to the development of the cancer.
Professor Heery, head of the Division of Molecular and Cellular Sciences, said: “At least 50 genes have been identified that are involved in gene fusions associated with leukaemia. The key question is to discover how MOZ-TIF2 and similar fusion proteins affect cell function.
“This will be critical in the future discovery of potential new drug treatments for patients with this form of the disease.”
AICR’s scientific adviser Dr Mark Matfield believes the work will have important implications in better understanding a type of leukaemia for which the exact causes are, as yet, unknown.
“This is an aggressive form of cancer and although it can affect all ages it is more common in older people, with slightly more reported cases in men. The main lab tests used in diagnosis are a full blood count and bone marrow biopsy,” he said.
“Without treatment AML will rapidly cause death, but with modern treatment protocols the cure rate has improved significantly in patients who are under 60. Older people tend to do less well, partly because they are often unable to receive the very intensive therapy needed for effective management of the disease.”
Derek Napier, AICR’s Chief Executive, said the grant was in line with the charity’s policy of funding the most exciting and novel approaches to research worldwide.
“We believe it important to fund work that pushes the boundaries and Professor Heery and Dr Kindle are charged with tackling a great scientific challenge that could in future change the lives of tens of thousands of people in the UK across the world.”
Emma Thorne | alfa
Flow of cerebrospinal fluid regulates neural stem cell division
21.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
21.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology