The new work, reported in the Nov. 16 issue of the journal Nature, illustrates the genetic changes required for the H5N1 avian influenza virus to adapt to easily recognize the receptors that are the gateway to human cells.
"We identified two changes that are important," says Yoshihiro Kawaoka, the senior author of the Nature paper and a virologist at the University of Wisconsin-Madison School of Veterinary Medicine. "Both changes are needed for the H5N1 virus to recognize human receptors."
The new report provides a molecular blueprint for the genetic changes required to transform a virus that only infects birds to a virus capable of easily recognizing human receptors. Receptors are molecules on the surface of cells that permit the virus to dock with the cell and commandeer it to initiate a cascade of infection. By knowing what genetic changes are required for the virus to easily infect human cells, it may be possible to detect the emergence of pandemic strains earlier, providing public health officials and vaccine manufacturers with precious time to prepare for a global outbreak of highly pathogenic influenza. To be successful, a virus must be able to recognize and attach to a host cell. But human and avian influenza viruses recognize different cell receptors. Avian flu viruses have demonstrated an ability to evolve to easily infect humans by exchanging genes with human viruses that subsequently permit them to recognize human receptor molecules and gain easy access to cells, typically in the human respiratory system.
The change is thought to occur when human patients are exposed at the same time to a human flu virus and an avian flu virus. Most viruses, including influenza, readily swap genes with one another.
In the new study, conducted by an international team of researchers, the viruses isolated from human patients in Vietnam and Thailand could recognize both human and avian cell receptors. By contrast, the viruses found in chickens and ducks could only recognize the receptors on avian cells.
The work helps flesh out the changes that have occurred in the worrisome strain of avian influenza virus known as H5N1, a strain some fear could be the organism that will trigger a pandemic of virulent human influenza. The avian virus has already changed dramatically from when it was first identified in 1997, says Kawaoka, who also holds an appointment at the University of Tokyo.
"There are big differences between the virus first found in 1997 and the virus we see now," Kawaoka explains. "We are watching this virus turn itself into a human pathogen."
The mutations found by Kawaoka's group have not yet conferred a complete ability on avian flu to easily recognize the topography of human cells, but they are key steps on that pathway. More mutations, says Kawaoka, will be required for the virus to fully adapt to humans, but it is not known how many mutations are needed for such a change.
However, if scientists are able to continue to monitor and secure viral isolates from humans infected with bird flu, they may be able to map a mutation trajectory that will help predict when the avian virus will cross the threshold to become a human pathogen.
The last two flu pandemics in 1957 and 1968 were caused by avian viruses that had accumulated enough genetic mutations to be considered hybrids of animal and human viruses, Kawaoka notes.
Yoshihiro Kawaoka | EurekAlert!
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research