Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NYU researchers developing molecular delivery vehicles for genetic therapies

14.11.2006
Researchers at New York University are working to develop molecular delivery vehicles that can be used to transport nucleic acids into diverse cell types, which may lead to eventual applications in genetic therapies. Their work is described as part of the cover story in the Nov. 13 issue of the American Chemical Society publication Chemical and Engineering News.

Scientists have been exploring RNA interference (RNAi) as a gene therapy technique to silence genes that are improperly produced. The "RNAi" approach requires the delivery into the cell of short pieces of the genetic material Ribonucleic Acid (RNA).

These synthetic short RNA "oligos" can then pair with specific sites in the cell's own RNA, targeting the genetic messages for destruction and turning off expression of the corresponding genes. However, the widespread clinical use of this genetic therapy relies upon technical improvements, including new delivery vehicles such as the one Kent Kirshenbaum, an assistant professor in NYU's Department of Chemistry, and colleagues present in their work.

The NYU researchers use a modular linear molecule to deliver therapeutic RNA into cells. The molecule has a positively charged site that forms favorable stabilizing interactions with the negatively charged RNA, and a fatty component that interacts with cell membranes. The molecules and RNA form complexes, which protect the RNA from being degraded and deliver it to cells. As a result, the targeted deleterious genes are silenced.

... more about:
»Genetic »RNA »delivery

Their research concentrates on making the transition from the lab into real-life smoother. Their linear molecule can be used to deliver small therapeutic RNAs into cell types that are much more representative of cellular targets that investigators are likely to encounter in clinical situations.

Kirshenbaum and his coworkers are now focused on understanding the physical chemical characteristics that give enhanced activity to their molecule, and then use the knowledge to generate a set of more sophisticated delivery reagents for siRNA.

"Our goal is to develop a platform that would allow us to create a library that could be used in different settings or for delivery to different cell types," he told Chemical and Engineering News.

James Devitt | EurekAlert!
Further information:
http://www.nyu.edu

Further reports about: Genetic RNA delivery

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>