Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New way to combat cancer

14.11.2006
In many forms of cancer the tumor encounters a lack of oxygen, a condition that the tumor tries to prevent in various ways.

A research group with its base at Lund University in Sweden is now presenting findings that may make it possible to attack the tumor precisely via these defense mechanisms in the future

The natural thing for tissue to do when there is a lack of oxygen is to try to stimulate the formation of new blood vessels in the area. Tumors adapt in this way, too. Two substances that are key to this process are called HIF-1 and HIF-2 (hypoxia inducible factors). Both help the tumor create new blood vessels.

HIF-1 has been an object of interest to scientists for several years and is already seen as a treatment target in the drug industry. Under the direction of Professor Sven Påhlman, researchers at Lund University together with colleagues at the Karolinska Institute and in Valencia have now managed to show that HIF-2 also plays a crucial role in the reaction of the tumor. Their studies of the pediatric tumor neuroblastoma show that HIF-1 plays the most important role initially, whereas HIF-2 is of greater importance if the lack of oxygen is prolonged.

... more about:
»HIF-1 »HIF-2 »Oxygen »blood vessel

"In other words, merely attacking HIF-1 might not be enough. You need a treatment that knocks out both factors," says Sven Påhlman.

The supply of oxygen to tumors is a complex and partly controversial chapter in cancer care. Many drugs now on their way to market aim to stop the flow of oxygen to the tumor in order to get them to die. But the principle is not always easy to put into practice. The flow of oxygen to the tumor must be eliminated completely­-a tumor that 'merely' experiences a shortage of oxygen risks becoming even more aggressive.

"One reason for this is that the tumor gets help from HIF-1 and HIF-2, for instance, to stimulate the growth of new blood vessels. Through these vessels they can release cells that lead to metastases, daughter growths in other parts of the body. Another reason is that oxygen-deprived tumors become more resistant to both chemotherapy and radiation," explains Sven Påhlman.

His research team has now been able to demonstrate that high levels of HIF-2 in the pediatric tumor neuroblastoma are associated with a poor prognosis. It should therefore be possible to use the level of HIF-2 as a marker for the diagnosis and prognosis of neuroblastoma. It should also be feasible to develop the blocking of HIF-2 into a future treatment of the disease. The researchers have carried out experiments on laboratory animals to this effect and have attained favorable results

The discovery is being honored with a cover illustration in the international journal Cancer Cell.

Ingela Björck | idw
Further information:
http://www.vr.se
http://www.cancercell.org/content/article/abstract?uid=PIIS153561080600290X

Further reports about: HIF-1 HIF-2 Oxygen blood vessel

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>