Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New way to combat cancer

14.11.2006
In many forms of cancer the tumor encounters a lack of oxygen, a condition that the tumor tries to prevent in various ways.

A research group with its base at Lund University in Sweden is now presenting findings that may make it possible to attack the tumor precisely via these defense mechanisms in the future

The natural thing for tissue to do when there is a lack of oxygen is to try to stimulate the formation of new blood vessels in the area. Tumors adapt in this way, too. Two substances that are key to this process are called HIF-1 and HIF-2 (hypoxia inducible factors). Both help the tumor create new blood vessels.

HIF-1 has been an object of interest to scientists for several years and is already seen as a treatment target in the drug industry. Under the direction of Professor Sven Påhlman, researchers at Lund University together with colleagues at the Karolinska Institute and in Valencia have now managed to show that HIF-2 also plays a crucial role in the reaction of the tumor. Their studies of the pediatric tumor neuroblastoma show that HIF-1 plays the most important role initially, whereas HIF-2 is of greater importance if the lack of oxygen is prolonged.

... more about:
»HIF-1 »HIF-2 »Oxygen »blood vessel

"In other words, merely attacking HIF-1 might not be enough. You need a treatment that knocks out both factors," says Sven Påhlman.

The supply of oxygen to tumors is a complex and partly controversial chapter in cancer care. Many drugs now on their way to market aim to stop the flow of oxygen to the tumor in order to get them to die. But the principle is not always easy to put into practice. The flow of oxygen to the tumor must be eliminated completely­-a tumor that 'merely' experiences a shortage of oxygen risks becoming even more aggressive.

"One reason for this is that the tumor gets help from HIF-1 and HIF-2, for instance, to stimulate the growth of new blood vessels. Through these vessels they can release cells that lead to metastases, daughter growths in other parts of the body. Another reason is that oxygen-deprived tumors become more resistant to both chemotherapy and radiation," explains Sven Påhlman.

His research team has now been able to demonstrate that high levels of HIF-2 in the pediatric tumor neuroblastoma are associated with a poor prognosis. It should therefore be possible to use the level of HIF-2 as a marker for the diagnosis and prognosis of neuroblastoma. It should also be feasible to develop the blocking of HIF-2 into a future treatment of the disease. The researchers have carried out experiments on laboratory animals to this effect and have attained favorable results

The discovery is being honored with a cover illustration in the international journal Cancer Cell.

Ingela Björck | idw
Further information:
http://www.vr.se
http://www.cancercell.org/content/article/abstract?uid=PIIS153561080600290X

Further reports about: HIF-1 HIF-2 Oxygen blood vessel

More articles from Life Sciences:

nachricht 'Lipid asymmetry' plays key role in activating immune cells
20.02.2018 | Biophysical Society

nachricht New printing technique uses cells and molecules to recreate biological structures
20.02.2018 | Queen Mary University of London

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

'Lipid asymmetry' plays key role in activating immune cells

20.02.2018 | Life Sciences

MRI technique differentiates benign breast lesions from malignancies

20.02.2018 | Medical Engineering

Major discovery in controlling quantum states of single atoms

20.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>