Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pourquié Lab Identifies Genes Involved in Formation of Vertebral Precursors

14.11.2006
Mary Lee Dequeant, Ph.D., a Predoctoral Researcher at the Stowers Institute for Medical Research, and Olivier Pourquié, Ph.D., Stowers Institute Investigator and an investigator with the Howard Hughes Medical Institute, are the first and last authors, respectively, on a paper that identifies a network of cyclic genes that shed light on the molecular basis of spine formation in the embryo.

The paper was published on Science Express, the advanced publication Web site of Science Magazine on Nov. 9, 2006.

Dr. Pourquié’s lab has long studied the formation of the spine and the role of an internal mechanism — the clock oscillator — that regulates the formation somites, the precursors of vertebrae. In their most recent findings, the team used the mouse model to demonstrate how the clock drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the Notch/FGF and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.

“Our findings shed light on a fundamental aspect of the architecture of the spine by demonstrating the implication of a large network of genes involved in controlling the periodicity of the production of vertebral precursors in the embryo,” said Dr. Pourquié.

... more about:
»Pourquié »Stowers Institute »oscillator

“I’m excited about this work because mutation of the genes involved in the segmentation clock oscillator can cause crippling diseases in humans, such as congenital scoliosis,” said Dr. Dequeant. “Our work identified many novel genes associated to the oscillator whose mutation could lead to such disease.”

Additional contributing authors from the Stowers Institute include Earl Glynn, Scientific Programmer; Karin Gaudenz, Research Specialist I; Matthias Wahl, Postdoctoral Research Associate; Jie Chen, Visiting Scientist; and Arcady Mushegian, Director of Bioinformatics Center.

Dr. Pourquié holds an appointment as an Associate Professor in the Department of Pathology & Laboratory Medicine at The University of Kansas School of Medicine.

About the Stowers Institute

Housed in a 600,000 square-foot state-of-the-art facility on a 10-acre campus in the heart of Kansas City, Missouri, the Stowers Institute for Medical Research conducts basic research on fundamental processes of cellular life. Through its commitment to collaborative research and the use of cutting-edge technology, the Institute seeks more effective means of preventing and curing disease. The Institute was founded by Jim and Virginia Stowers, two cancer survivors who have created combined endowments of $2 billion in support of basic research of the highest quality.

Marie Jennings | EurekAlert!
Further information:
http://www.stowers-institute.org

Further reports about: Pourquié Stowers Institute oscillator

More articles from Life Sciences:

nachricht More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>