Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pourquié Lab Identifies Genes Involved in Formation of Vertebral Precursors

14.11.2006
Mary Lee Dequeant, Ph.D., a Predoctoral Researcher at the Stowers Institute for Medical Research, and Olivier Pourquié, Ph.D., Stowers Institute Investigator and an investigator with the Howard Hughes Medical Institute, are the first and last authors, respectively, on a paper that identifies a network of cyclic genes that shed light on the molecular basis of spine formation in the embryo.

The paper was published on Science Express, the advanced publication Web site of Science Magazine on Nov. 9, 2006.

Dr. Pourquié’s lab has long studied the formation of the spine and the role of an internal mechanism — the clock oscillator — that regulates the formation somites, the precursors of vertebrae. In their most recent findings, the team used the mouse model to demonstrate how the clock drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the Notch/FGF and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.

“Our findings shed light on a fundamental aspect of the architecture of the spine by demonstrating the implication of a large network of genes involved in controlling the periodicity of the production of vertebral precursors in the embryo,” said Dr. Pourquié.

... more about:
»Pourquié »Stowers Institute »oscillator

“I’m excited about this work because mutation of the genes involved in the segmentation clock oscillator can cause crippling diseases in humans, such as congenital scoliosis,” said Dr. Dequeant. “Our work identified many novel genes associated to the oscillator whose mutation could lead to such disease.”

Additional contributing authors from the Stowers Institute include Earl Glynn, Scientific Programmer; Karin Gaudenz, Research Specialist I; Matthias Wahl, Postdoctoral Research Associate; Jie Chen, Visiting Scientist; and Arcady Mushegian, Director of Bioinformatics Center.

Dr. Pourquié holds an appointment as an Associate Professor in the Department of Pathology & Laboratory Medicine at The University of Kansas School of Medicine.

About the Stowers Institute

Housed in a 600,000 square-foot state-of-the-art facility on a 10-acre campus in the heart of Kansas City, Missouri, the Stowers Institute for Medical Research conducts basic research on fundamental processes of cellular life. Through its commitment to collaborative research and the use of cutting-edge technology, the Institute seeks more effective means of preventing and curing disease. The Institute was founded by Jim and Virginia Stowers, two cancer survivors who have created combined endowments of $2 billion in support of basic research of the highest quality.

Marie Jennings | EurekAlert!
Further information:
http://www.stowers-institute.org

Further reports about: Pourquié Stowers Institute oscillator

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

DGIST develops 20 times faster biosensor

24.04.2017 | Physics and Astronomy

Nanoimprinted hyperlens array: Paving the way for practical super-resolution imaging

24.04.2017 | Materials Sciences

Atomic-level motion may drive bacteria's ability to evade immune system defenses

24.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>