Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UVA Researchers Study Link Between "Alzheimer's Gene" And Protection from Early Childhood Diarrhea

13.11.2006
Researchers at the University of Virginia School of Medicine and Federal University of Ceará in Brazil have joined forces to study if the gene believed to contribute to Alzheimer's protects children from the developmental stresses of early childhood diarrhea.
"In earlier studies, we found that shantytown children in Northeast Brazil who suffer from early childhood diarrhea and malnutrition suffered from lasting physical and cognitive consequences. However, some children who have the same diarrhea and malnutrition are protected from the developmental problems if they have the "Alzheimer's gene" (APOE4)," says Dr. Richard Guerrant, founder and director of the Center for Global Health at the University of Virginia School of Medicine. "Basically, we believe this gene protects the children early in life by helping them survive severe malnutrition, but the same gene potentially contributes to a multitude of problems later in life."

Guerrant and colleagues at Federal University of Ceará recently received a $1.3 million grant from the National Institute of Child and Human Development to study the striking link. Guerrant and Dr. Aldo A. M. Lima, professor and director of the Clinical Research Unit & Institute of Biomedicine at Federal University of Ceará have a 25-year collaboration addressing children's health and development issues. Dr. Lima and Dr. Reinaldo Oriá are working as the principal investigators in Brazil.

Severe diarrhea and its accompanying malnutrition kill more than 3 million people worldwide each year and developmentally impair many millions more children who survive repeated bouts of diarrhea, while Alzheimer's afflicts more than 20 million people worldwide each year.

"This might have important implications for Brazil and other developing countries, where diabetes and cardiovascular disease are also becoming critical issues in public health," says Oriá, an associate professor at Federal University of Ceará and a former research fellow at the University of Virginia. Oria says the primary goal of the study will be to develop interventional therapies based on critical nutrients which children need for their cognitive and physical development.

... more about:
»Ceará »Consequences »Guerrant »malnutrition

In studies in mice at UVa, these researchers have shown that those mice who do not have the APOE4 gene suffer far worse malnutrition when they are weaned early. Oria says they are looking to see if arginine, an amino acid, can help lessen the devastating consequences of severe diarrhea and malnutrition.

In addition, Guerrant says the research will also shed further light on situations where negative genetic traits are found to have beneficial effects that likely help to explain their presence in human evolution. An example of this phenomenon, called a balanced polymorphism, is sickle cell anemia, a genetic disease in which a double "dose" of the sickle cell gene causes red blood cells to form odd shapes and results in pain and anemia. A single "dose" of the same gene, however, makes a person resistant to malaria, a deadly tropical disease.

Oria adds that if the APOE4 gene indeed proves to be a balanced polymorphism, this could greatly help us understand and reduce the long-term impact of diarrhea and malnutrition. He says the genetic imprint early in life due to the "switch-on" of genes to sustain body mass, may have lasting consequences later in life. This genetic "switch" could elucidate ways to "turn-on" the protection when they are most vulnerable and then "turn-off" the genetic switch which helped them in their youth, but will cause them more problems as they age.

"We are very excited about this ongoing research with the promise of hope and better health it offers to millions of children silently suffering the devastating consequences of diarrhea and malnutrition worldwide," Guerrant says.

David Foreman | EurekAlert!
Further information:
http://www.virginia.edu

Further reports about: Ceará Consequences Guerrant malnutrition

More articles from Life Sciences:

nachricht BigH1 -- The key histone for male fertility
14.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)

nachricht Guardians of the Gate
14.12.2017 | Max-Planck-Institut für Biochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Plasmonic biosensors enable development of new easy-to-use health tests

14.12.2017 | Health and Medicine

New type of smart windows use liquid to switch from clear to reflective

14.12.2017 | Physics and Astronomy

BigH1 -- The key histone for male fertility

14.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>