Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New biomarkers for lupus found

A Wake Forest University School of Medicine team believes it has found biomarkers for lupus that also may play a role in causing the disease.

The biomarkers are micro-ribonucleic acids (micro-RNAs), said Nilamadhab Mishra, M.D. He and colleagues reported at the American College of Rheumatology meeting in Washington that they had found profound differences in the expression of micro-RNAs between five lupus patients and six healthy control patients who did not have lupus.

"We are the first to show that these micro-RNAs are a problem in human lupus," said Mishra, an assistant professor of rheumatology.

Mishra said microRNAs are a class of small chains of ribonucleic acid that have important regulatory functions in the body, particularly in suppressing genes. (RNA serves as the template for translation of genes into proteins.)

... more about:
»HDIs »Lupus »MicroRNA »Mishra »micro-RNAs

The research is part of Mishra's broader focus on histones, the tiny spools in the nuclei of cells around which DNA winds and compacts when it is not in the process of copying in cell division. Changes in these histones, called epigentic changes, can alter gene expression and the proteins these genes produce without altering the underlying DNA.

In the new study, the researchers found 40 microRNAs in which the difference in expression between the lupus patients and the controls was more than 1.5 times, and focused on five micro-RNAs where the lupus patients had more than three times the amount of the microRNAs as healthy controls, and one, called miR 95 where the lupus patients had just one third of the gene expression of the microRNA of the controls.

The team reported the lesser amount of miR 95 "results in aberrant gene expression in lupus patients."

Furthermore, Mishra said, the microRNAs are associated with enzymes called histone deacetylases which provide "further rationale for the use of histone deacetylase inhibitors (HDIs) for the treatment of lupus."

Mishra has shown that HDIs reset the histone modifications. He and his colleagues are investigating two HDIs – TSA (Trichostatin A) and SAHA (suberoylanilide hydroxamic acid ) – in lupus patients and have reported positive results against a number of lupus symptoms and conditions.

Coauthors with Mishra on this study are Kerri Keiger, Ph.D., and Emmanuel Labourier, Ph.D., of Ambion Inc. in Austin, Texas, which makes RNA-based research products for the life sciences markets.

In a second presentation, Mishra discussed his hypothesis that environmental factors trigger histone modifications that activate a type of white blood cell called the B cell and turn these cells into self-destructive attackers, a key element in lupus, an autoimmune disorder.

Mishra said removing these activated B cells is one current treatment for lupus. "The lupus patients have activated B cells that cause antibody production and kidney disease, but we don't know why," he said.

But he is continuing to pursue resetting part of the epigenetic code as a way to improve lupus treatment.

"We demonstrated that the response to bacterial and viral byproducts induce B-cell activation through the epigenetic mechanism," he said. These changes lead to activation of the histone deacetylase enzymes. The HDIs stop this activation.

Robert Conn | EurekAlert!
Further information:

Further reports about: HDIs Lupus MicroRNA Mishra micro-RNAs

More articles from Life Sciences:

nachricht First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife

nachricht Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Ice shelf vibrations cause unusual waves in Antarctic atmosphere

25.10.2016 | Earth Sciences

Fluorescent holography: Upending the world of biological imaging

25.10.2016 | Power and Electrical Engineering

Etching Microstructures with Lasers

25.10.2016 | Process Engineering

More VideoLinks >>>