Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers identify molecule that causes destructive lung inflammation in cystic fibrosis patients

08.11.2006
Discovery offers scientists a target for developing new treatments that could improve quality of life

Scientists at Children's Hospital of Pittsburgh of UPMC have identified a protein that is critical to the development of inflammation during lung infection in patients with cystic fibrosis (CF). The identification of this protein, called interleukin-23 (IL-23), is an important finding that gives researchers a specific target for developing new therapies.

In June 2005, Children's and University of Pittsburgh researchers led by Children's pulmonologist and immunologist Jay K. Kolls, MD, reported that IL-23 and another cytokine, interleukin-17, are elevated in CF patients with chronic lung infections. The latest research by Dr. Kolls and Children's pulmonologist Patricia Dubin, MD, pinpoints IL-23 as the crucial mediator to this inflammatory response. Results of this study are now published online in the American Journal of Physiology-Lung Cellular and Molecular Physiology.

Many patients with CF develop chronic lung infections from a strain of bacteria known as Pseudomonas aeruginosa. During chronic infection, the inflammatory response is never "shut off", and the continuous inflammation, mediated by IL-23 and other cytokines, may eventually lead to lung damage.

... more about:
»IL-23 »cystic »fibrosis »inflammation »inflammatory

"Understanding the role IL-23 plays in the inflammatory pathway of CF patients is a major step forward that could lead to the development of new therapies to block this inflammation," said Dr. Kolls, chief of the Division of Pulmonary Medicine, Allergy and Immunology at Children's and professor of Pediatrics and Immunology at the University of Pittsburgh School of Medicine. "For patients with chronic infections associated with CF, this eventually could mean a prolonged life span and an improved quality of life."

Examining IL-23's importance in the inflammation pathway is a "new and different" approach than that taken by other CF researchers, according to Dr. Dubin, an assistant professor of Pediatrics at the University of Pittsburgh School of Medicine. "Currently, the anti-inflammatory therapies that we have for CF patients, steroids and non-steroidal anti-inflammatory drugs, are non-specific and can cause debilitating side effects such as the exacerbation of diabetes and glucose intolerance, as well as bone loss. The identification of specific inflammatory mediators like IL-23 opens the door to developing targeted anti-inflammatory treatments which may have fewer side effects."

CF is an inherited disease characterized by an abnormality in the body's salt-, water- and mucus-making cells. It is chronic, progressive and life-shortening. About 30,000 people in the United States have CF and about 1,000 babies are born with it each year. The life expectancy of a child born with CF is 36.5 years. The Antonio J. and Janet Palumbo CF Center at Children's follows more than 430 patients.

Children with CF have an abnormality in the function of a cell protein called the cystic fibrosis transmembrane regulator. This affects the flow of water and certain salts in and out of the body's cells, leading to the production of abnormally thick mucus. The thickened mucus can affect many organs and body systems, including the sinuses and lungs, pancreas, liver, gallbladder, intestines, and reproductive and sweat glands. In the sinuses and lungs, this thickened mucus allows bacteria that would normally be cleared from the airways to multiply and cause chronic infection.

Marc Lukasiak | EurekAlert!
Further information:
http://www.chp.edu

Further reports about: IL-23 cystic fibrosis inflammation inflammatory

More articles from Life Sciences:

nachricht For a chimpanzee, one good turn deserves another
27.06.2017 | Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPIMIS)

nachricht New method to rapidly map the 'social networks' of proteins
27.06.2017 | Salk Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Touch Displays WAY-AX and WAY-DX by WayCon

27.06.2017 | Power and Electrical Engineering

Drones that drive

27.06.2017 | Information Technology

Ultra-compact phase modulators based on graphene plasmons

27.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>