Researchers at the John Innes Centre (JIC) in Norwich have used state-of-the-art technology to study a nanomachine in soil bacteria called the Tat system, which the bacteria use to secrete a range of proteins that help them digest food and compete with other microorganisms in the soil.
The scientists' latest work, published today in the respected journal PNAS, identifies which proteins are exported via the Tat system, revealing that this system is used by more proteins than previously thought. The biotechnology industry already uses bacteria to make proteins to use in products such as biological washing powder or pharmaceuticals, but some are difficult to produce using current methods. By harnessing the Tat system, the scientists hope that it will be easier to make these proteins for biotechnological and biomedical purposes.
The Tat nanomachine selects which proteins to secrete by recognising a short signal sequence attached to the end of the protein, explains Professor Tracy Palmer who has an MRC Fellowship with the University of East Anglia, " Our collaborators at the University of Pennsylvania have developed a computer program to search the bacterial genome to predict which proteins use the Tat system, and in this study we have verified their results experimentally and found a significant number of signals that are recognised by this system. The next step is to attach these signals to medically important proteins so they can be secreted by the bacteria using the Tat system."
The foundation work for this project was started as part of the Biotechnology and Biological Sciences Research Council' s (BBSRC) Exploiting Genomics Initiative; more recently Prof Palmer's team has joined forces with the "Tat Machine Project", an EU-funded consortium of researchers from across Europe studying the Tat system. In addition to using the Tat nanomachine to improve production of biopharmaceuticals, the consortium are studying the system in several different types of bacteria, including pathogenic species like E. coli O157 and Pseudomonas aeruginosa to explore Tat as a potential target for new antibiotics.
Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel
Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
26.04.2017 | Life Sciences
26.04.2017 | Physics and Astronomy
26.04.2017 | Earth Sciences