Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists show gene reverts cancer genes to normal, predicts breast cancer prognosis

02.11.2006
Scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have shown that the activity of a gene that commandeers other cancer-causing genes, returning them to normal, can predict the prognosis of an individual with breast cancer.

The gene, Dachshund, normally regulates eye development and development of other tissues, in essence playing a role in determining the fate of some types of cells. Richard Pestell, M.D., Ph.D., director of the Kimmel Cancer Center at Jefferson and professor and chair of cancer biology at Jefferson Medical College, and co-workers looked at cancer cells from more than 2,000 breast cancer patients and found that this commandeering or "organizing" ability is increasingly lost in cancer cells and associated with the progression of disease. The more the gene is expressed in breast cancer, the researchers saw, the better the patient did. The scientists report their findings in October in the journal Molecular and Cellular Biology.

"This is a new type of gene in cancer that commandeers the cancerous genes and returns them to normal," says Dr. Pestell. "The standard cancer treatment strategy has been to block the proliferation of cancer cells or cause them to die. This is quite different. We've shown that the Dachshund gene reverts the cancerous phenotype and turns the cell back to a pre-malignant state. Cells don't die, but rather, they revert.

"It's a bad prognostic feature if you lose this organizer gene," he says, adding that it could be used as a prognostic marker for breast cancer.

... more about:
»breast cancer »cancer cells »dachshund

In the work, the researchers showed that Dachshund could block breast cancer growth in mice and also could halt breast cancer from invading other tissues in cell culture. They also found that the gene inhibits the expression of the cyclin D1 gene, a cancer-causing gene that is overexpressed in about half of all breast cancers.

The group used microarray technology – silicon chips containing ordered selections of genetic material upon which sample material can be tested – to analyze Dachshund expression during the development of breast cancer. The scientists compared normal breast cells, pre-cancerous "in situ" cells and more than 2,100 breast cancer cell samples. Dachshund gene expression was "significantly reduced" in breast cancer.

The average survival was almost 40 months better in women in whom their breast cancer continued to express Dachshund.

Dr. Pestell notes that the expression of Dachshund correlates with tumor size, stage and metastasis, with its expression greatly reduced in metastatic breast cancer cells. Dr. Pestell's team is examining other cell fate-determining genes in an attempt to identify new therapeutics for breast cancer and metastasis.

Steve Benowitz | EurekAlert!
Further information:
http://www.jefferson.edu

Further reports about: breast cancer cancer cells dachshund

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>