Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New molecular method reveals ‘conversations’ between proteins in cells

30.10.2006
By further refining a molecular method they previously pioneered, researchers at Uppsala University have managed to uncover interactions between protein molecules in human cells. The method, described in the latest issue of the scientific journal Nature Methods, opens entirely new potential for understanding the role of proteins in various diseases.

Proteins build up the body’s cells and tissues, and knowledge of the human genome has entailed that scientists today know all the proteins our bodies can generate. It is known that many pathologies can be tied to changes in proteins, so it is important for us to increase our knowledge of what proteins bind to each other, how they work together in cells, and how these processes impact various disturbances.

“With this new method we can see how individual proteins interact directly in cells, which has not been possible until now. In the past scientists have largely studied how much of a protein is present in various tissues, but now we can study how they function as well,” says researcher Ola Söderberg, a member of the team that carried out the study within the framework of the team’s research project on molecular tools.

The method is a further elaboration of the so-called proximity ligation test that was recently developed by the same research group. Proximity ligation means that proteins shown to be present bring about the formation of DNA strings that can be detected effectively and with a high degree of sensitivity. With the new modification, it is now possible to show just where in a cell or tissue sample the interacting proteins are to be found. Even individual protein molecules can be singled out.

... more about:
»Molecular »method

“The method may be of great importance to scientists in their understanding of cell processes and ultimately may lead to more accurate examinations of tissue sample in diseases and to very early diagnosis,” says Professor Ulf Landegren, who directs the research team.

Anneli Waara | alfa
Further information:
http://www.nature.com/nmeth/journal/vaop/ncurrent/index.html

Further reports about: Molecular method

More articles from Life Sciences:

nachricht Molecular microscopy illuminates molecular motor motion
26.07.2017 | Penn State

nachricht New virus discovered in migratory bird in Rio Grande do Sul, Brazil
26.07.2017 | Fundação de Amparo à Pesquisa do Estado de São Paulo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

CCNY physicists master unexplored electron property

26.07.2017 | Physics and Astronomy

Molecular microscopy illuminates molecular motor motion

26.07.2017 | Life Sciences

Large-Mouthed Fish Was Top Predator After Mass Extinction

26.07.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>