Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mouse DNA to aid biomedical research

27.10.2006
Researchers announced today that they have successfully resequenced the DNA of 15 mouse strains most commonly used in biomedical research.

More than 8.3 million single nucleotide polymorphisms (SNPs) were discovered among the genomes of the 15 mouse strains and the data are now publicly available. These new data will help researchers better understand complex genetic traits, such as why some individuals are more susceptible to certain diseases, and will serve as a valuable resource in determining how environmental agents influence the development of disease.

Single Nucleotide Polymorphisms, or SNPs (known as "snips"), are single genetic changes, or variations, that can occur within a DNA sequence. Because mice and humans share many of the same fundamental biological and behavioral processes, including gene functions, these data will help researchers understand human genetic susceptibility to almost 200 diseases such as Parkinson's, cancer, diabetes, heart and lung diseases, reproductive diseases, and asthma and other childhood diseases, which are affected by exposure to environmental substances.

"Making this wealth of data freely available to the research community is a significant milestone," said David A. Schwartz. M.D., director of the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, which funded the research. "Each mouse strain is genetically unique. Now that we know the DNA variations for these mouse strains, we can compare the genetic makeup of one strain that acquires a certain disease to another strain that does not get the same disease. In this way researchers gain insight into the same processes that may cause one human to get a disease while another human in the same environment remains disease-free."

... more about:
»DNA »Perlegen »SNP »Variation »strain

The "Resequencing and SNP Discovery Project" began less than two years ago through a contract between the National Toxicology Program at NIEHS and Perlegen Sciences, Inc. of Mountain View CA. Perlegen scientists conducted the project using as a standard reference the 2003 DNA sequencing of the C57BL/6J mouse strain -- the very first mouse strain to undergo DNA sequencing. The mouse models included in the resequencing project are: 129S1/SvImJ, A/J, AKR/J, BALB/cByJ, BTBR T+ tf/J, C3H/HeJ, CAST/EiJ, DBA/2J, FVB/NJ, MOLF/EiJ, KK/HlJ, NOD/LtJ, NZW/LacJ, PWD/PhJ, and WSB/EiJ. The 15 mouse strains were carefully chosen because of their routine use as research models and their genetic diversity. The project used the same high-density oligonucleotide array technology that was used to discover common DNA variation in the human genome.

"Perlegen Sciences was excited to perform this scientific work, because it promised to provide an extremely valuable resource. We believe the data will generate a lot of knowledge about complex genetic traits," said Kelly Frazer, Vice President of Genomics at Perlegen Sciences, Inc.

"This project was highly anticipated by scientists. Now, we can go to our computer, click on the mouse strain we want to use, see the sequence variations for that strain and compare it to the others," said David Threadgill, Ph.D., an expert in mouse models of disease at the University of North Carolina, Chapel Hill. "If we use multiple strains, we can then look at the data after the animals are exposed to an environmental substance and compare the genetic differences between the strains that acquired a disease and those that did not. This will help us begin to identify causes of differential susceptibility to disease."

"These mouse data will aid in our understanding of 'counterpart' genes in humans, the corresponding molecular and biological pathways the lead to disease susceptibility, and the environmental agents that trigger the development of disease in susceptible people," said David Christiani, M.D., Professor of Medicine at Harvard Medical School and Professor of Occupational Medicine and Epidemiology at Harvard School of Public Health. "The data will also be a great resource for pharmaceutical companies that are developing new treatments for disease."

Robin Mackar | EurekAlert!
Further information:
http://www.niehs.nih.gov

Further reports about: DNA Perlegen SNP Variation strain

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>